Evidence map›Paper›PMID 41143002›Full record

ArticleiScience2025

Tissue microenvironment dictates the state of human iPSC-derived endothelial cells of distinct developmental origin in 3D cardiac microtissues.

Xu Cao, Maria Mircea, Sara Cascione, Atoosa Amel, Theano Tsikari, Francijna E van den Hil, Hailiang Mei, Katrin Neumann, Anna Alemany, Konstantinos Anastassiadis and 3 more

Abstract read
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In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Xu CaoDepartment of Anatomy and Embryology, Leiden University Medical Center, Einthovenweg 20, Leiden 2333ZC, the Netherlands.
Maria MirceaLeiden Institute of Physics, Leiden University, RA 2333, Leiden, the Netherlands.
Sara CascioneDepartment of Anatomy and Embryology, Leiden University Medical Center, Einthovenweg 20, Leiden 2333ZC, the Netherlands.
Atoosa AmelDepartment of Anatomy and Embryology, Leiden University Medical Center, Einthovenweg 20, Leiden 2333ZC, the Netherlands.
Theano TsikariDepartment of Anatomy and Embryology, Leiden University Medical Center, Einthovenweg 20, Leiden 2333ZC, the Netherlands.
Francijna E van den HilDepartment of Anatomy and Embryology, Leiden University Medical Center, Einthovenweg 20, Leiden 2333ZC, the Netherlands.
Hailiang MeiSequencing Analysis Support Core, Leiden University Medical Center, Leiden 2333ZA, the Netherlands.
Katrin NeumannStem Cell Engineering, Biotechnology Center, Center for Molecular and Cellular Bioengineering, Technische Universität Dresden, Dresden 01307, Germany.
Anna AlemanyDepartment of Anatomy and Embryology, Leiden University Medical Center, Einthovenweg 20, Leiden 2333ZC, the Netherlands.
Konstantinos AnastassiadisStem Cell Engineering, Biotechnology Center, Center for Molecular and Cellular Bioengineering, Technische Universität Dresden, Dresden 01307, Germany.
Christine L MummeryDepartment of Anatomy and Embryology, Leiden University Medical Center, Einthovenweg 20, Leiden 2333ZC, the Netherlands.
Stefan SemrauLeiden Institute of Physics, Leiden University, RA 2333, Leiden, the Netherlands.
Valeria V OrlovaDepartment of Anatomy and Embryology, Leiden University Medical Center, Einthovenweg 20, Leiden 2333ZC, the Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Each tissue and organ in the body has its own type of vasculature. Here, we demonstrate that organotypic vasculature for the heart can be recreated in a three-dimensional cardiac microtissue (MT) model composed of human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes (CMs), cardiac fibroblasts (CFs), and endothelial cells (ECs). ECs in cardiac MTs upregulated expression of markers enriched in human intramyocardial ECs, including

Indexed as

Developmental biologyStem cells researchTranscriptomics

Identifiers

PMID41143002
PMCPMC12546991

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.