Evidence map›Paper›PMID 41143001›Full record

ArticleiScience2025

The upregulation of GDF15 is controlled epigenetically by oncogenic TCF19 signaling in human hepatocellular carcinoma.

Yongqian Liu, Caiyu Yong, Mengyu Yang, Haoxiang Qi, Sijie Zheng, Menglan Wang, Xu Huang, Shujuan Zhao, Qiyi Zhang, Jianwei Han and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yongqian LiuSchool of Pharmacy and Department of Hepatology, The Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, Hangzhou 311121, P.R. China.
Caiyu YongSchool of Pharmacy and Department of Hepatology, The Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, Hangzhou 311121, P.R. China.
Mengyu YangSchool of Pharmacy and Department of Hepatology, The Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, Hangzhou 311121, P.R. China.
Haoxiang QiSchool of Pharmacy and Department of Hepatology, The Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, Hangzhou 311121, P.R. China.
Sijie ZhengSchool of Pharmacy and Department of Hepatology, The Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, Hangzhou 311121, P.R. China.
Menglan WangSchool of Pharmacy and Department of Hepatology, The Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, Hangzhou 311121, P.R. China.
Xu HuangSchool of Pharmacy and Department of Hepatology, The Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, Hangzhou 311121, P.R. China.
Shujuan ZhaoSchool of Pharmacy and Department of Hepatology, The Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, Hangzhou 311121, P.R. China.
Qiyi ZhangDepartment of Hepatobiliary and Pancreatic Surgery, The Second Affiliated Hospital Zhejiang University School of Medicine, Hangzhou 310050, P.R. China.
Jianwei HanJiande Hospital of Hangzhou Normal University, Hangzhou 311600, P.R. China.
Jie YingDepartment of Gastroenterology, Affiliated Nanjing Jiangbei Hospital of Xinglin College, Nantong University, Nanjing 210044, P.R. China.
Heng DongSchool of Pharmacy and Department of Hepatology, The Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, Hangzhou 311121, P.R. China.
Jianxiang ChenSchool of Pharmacy and Department of Hepatology, The Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, Hangzhou 311121, P.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Growth differentiation factor 15 (GDF15) plays an important role in the progression of hepatocellular carcinoma (HCC) and chronic liver disease, but its regulatory mechanisms are still unclear. Here, we found that the histone methylation reader protein transcription factor 19 (TCF19) was significantly positively correlated with and regulated GDF15 expression. RNA sequencing and chromatin immunoprecipitation (ChIP) revealed that TCF19 regulated GDF15 expression by directly binding to its promoter through the plant homeodomain (PHD) finger, recognizing H3K4me3. Coculture analysis suggests that TCF19 promoted the proliferation of HCC cells and the activation of hepatic stellate cell line LX2 by increasing the extracellular expression level of GDF15. We also found that Ras-related nuclear protein (RAN) might mediate the nuclear localization of TCF19, thereby affecting GDF15 expression and its pro-proliferative function. In summary, we demonstrated that GDF15 is positively regulated by TCF19, promoting the development of HCC.

Indexed as

CancerEpigeneticsMolecular network

Identifiers

PMID41143001
PMCPMC12546974

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.