ArticleiScience2025
Single-cell and spatial transcriptomics reveal intratumor heterogeneity and immune evasion in natural killer/T cell lymphoma.
Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Article
- The increased co-expression of SLC7A11 and PD-L1 was associated with poor prognosis in extranodal natural killer T-cell lymphoma patients.Cancer immunology, immunotherapy : CII · 2026Article
- Immunotherapy in NK/T-Cell Lymphoma: Mechanisms, Clinical Evidence, Resistance, and Emerging Multimodal Strategies.Cancers · 2026Review
- Epstein-Barr Virus Infection at Single-Cell Resolution.Journal of medical virology · 2026Review
- Deciphering immune heterogeneity in lung adenocarcinoma via machine learning-based Differential Phenotype Immune Score: TPX2 as a key biomarker for immunotherapy resistance.Frontiers in immunology · 2026Article
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Authors and funding
19 authors.
Funding
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Abstract
Natural killer/T cell lymphoma (NKTCL), an Epstein-Barr virus-associated malignancy, is a highly aggressive subtype of non-Hodgkin lymphoma. However, the intratumoral heterogeneity and the interaction within the tumor microenvironment (TME) remain insufficiently understood. Here, we utilized single-cell and spatial transcriptomics to analyze tissues from NKTCL patients, identifying five malignant meta-programs (MPs) with distinct functional pathways, differentiation trajectories, and spatial distributions. Notably, the MP3 subgroup emerges at the early stages of tumor differentiation, characterized by the hyperactivation of MYC signaling and an association with poor prognosis. Intriguingly, pharmacologic inhibition of fatty acid-binding protein 5 (FABP5) leads to the downregulation of c-Myc and significantly impairs tumor growth both
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