Emergence of mortality due to centrilobular to massive hepatic necrosis in western Canadian beef calves.

Devon J Wilson, Jennifer L Davies, Yanyun Huang, Vanessa E Cowan, Lindsay Rogers, Barbara J Wilhelm

Abstract readCase Reports

In one paragraph

Article in The Canadian veterinary journal = La revue veterinaire canadienne, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Devon J WilsonChilliwack, British Columbia V4Z 1H3 (Wilson); Diagnostic Services Unit, University of Calgary Faculty of Veterinary Medicine, 11877 85th Street NW, Calgary, Alberta T3R 1J3 (Davies, Rogers); Prairie Diagnostic Services Inc., 52 Campus Drive, Saskatoon, Saskatchewan S7N 5B4 (Huang); Veterinary Biomedical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, 52 Campus Drive, Saskatoon, Saskatchewan S7N 5B4 (Cowan); Western Canadian Animal Health Network, 52 Campus Drive, Saskatoon, Saskatchewan S7N 5B4 (Wilhelm).

Jennifer L DaviesChilliwack, British Columbia V4Z 1H3 (Wilson); Diagnostic Services Unit, University of Calgary Faculty of Veterinary Medicine, 11877 85th Street NW, Calgary, Alberta T3R 1J3 (Davies, Rogers); Prairie Diagnostic Services Inc., 52 Campus Drive, Saskatoon, Saskatchewan S7N 5B4 (Huang); Veterinary Biomedical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, 52 Campus Drive, Saskatoon, Saskatchewan S7N 5B4 (Cowan); Western Canadian Animal Health Network, 52 Campus Drive, Saskatoon, Saskatchewan S7N 5B4 (Wilhelm).

Yanyun HuangChilliwack, British Columbia V4Z 1H3 (Wilson); Diagnostic Services Unit, University of Calgary Faculty of Veterinary Medicine, 11877 85th Street NW, Calgary, Alberta T3R 1J3 (Davies, Rogers); Prairie Diagnostic Services Inc., 52 Campus Drive, Saskatoon, Saskatchewan S7N 5B4 (Huang); Veterinary Biomedical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, 52 Campus Drive, Saskatoon, Saskatchewan S7N 5B4 (Cowan); Western Canadian Animal Health Network, 52 Campus Drive, Saskatoon, Saskatchewan S7N 5B4 (Wilhelm).

Vanessa E CowanChilliwack, British Columbia V4Z 1H3 (Wilson); Diagnostic Services Unit, University of Calgary Faculty of Veterinary Medicine, 11877 85th Street NW, Calgary, Alberta T3R 1J3 (Davies, Rogers); Prairie Diagnostic Services Inc., 52 Campus Drive, Saskatoon, Saskatchewan S7N 5B4 (Huang); Veterinary Biomedical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, 52 Campus Drive, Saskatoon, Saskatchewan S7N 5B4 (Cowan); Western Canadian Animal Health Network, 52 Campus Drive, Saskatoon, Saskatchewan S7N 5B4 (Wilhelm).

Lindsay RogersChilliwack, British Columbia V4Z 1H3 (Wilson); Diagnostic Services Unit, University of Calgary Faculty of Veterinary Medicine, 11877 85th Street NW, Calgary, Alberta T3R 1J3 (Davies, Rogers); Prairie Diagnostic Services Inc., 52 Campus Drive, Saskatoon, Saskatchewan S7N 5B4 (Huang); Veterinary Biomedical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, 52 Campus Drive, Saskatoon, Saskatchewan S7N 5B4 (Cowan); Western Canadian Animal Health Network, 52 Campus Drive, Saskatoon, Saskatchewan S7N 5B4 (Wilhelm).

Barbara J WilhelmChilliwack, British Columbia V4Z 1H3 (Wilson); Diagnostic Services Unit, University of Calgary Faculty of Veterinary Medicine, 11877 85th Street NW, Calgary, Alberta T3R 1J3 (Davies, Rogers); Prairie Diagnostic Services Inc., 52 Campus Drive, Saskatoon, Saskatchewan S7N 5B4 (Huang); Veterinary Biomedical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, 52 Campus Drive, Saskatoon, Saskatchewan S7N 5B4 (Cowan); Western Canadian Animal Health Network, 52 Campus Drive, Saskatoon, Saskatchewan S7N 5B4 (Wilhelm).

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neonatal beef calves can succumb to several common diseases, including diarrhea and pneumonia, but death associated with hepatic disease is uncommon in this age group. Since 2022, a syndrome characterized by massive hepatic necrosis has been observed in western Canadian neonatal beef calves. This case series describes the clinical presentation, pathology, and ancillary testing done in 22 cases, highlighting the young age (1 to 5 d), varied symptoms observed, and unique liver pathology. Based on the pathology, a toxic cause was suspected, and toxic copper concentrations in kidney tissues were detected in 9/22 cases. Further investigation is required to understand this potentially emerging disease and prevent further occurrences. Key clinical message: Practitioners and pathologists should be aware of a new syndrome of hepatic necrosis in neonatal beef calves when evaluating neonatal calf mortality on western Canadian beef cattle operations. Further study is needed to understand the epidemiology of this condition.

Indexed as

Cattle DiseasesMassive Hepatic NecrosisAnimalsAnimals, NewbornCanadaCattleCopperLiverCopper

Identifiers

PMID41142973

PMCPMC12548676

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.