Evidence map›Paper›PMID 41142912›Full record

ArticlePatterns (New York, N.Y.)2025

S2S: A deep learning method for the radiological diagnosis of fine-grained diseases spanning screening to subtyping.

Ruijie Tang, Yuchen Guo, Hengrui Liang, Jianxing He, Yuerong Lizhu, Yaou Liu, Feng Xu

Abstract read
In one paragraph

Article in Patterns (New York, N.Y.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. From screening to subtyping in a single glance.Patterns (New York, N.Y.) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ruijie TangSchool of Software, Beijing National Research Center for Information Science and Technology (BNRist), Institute for Brain and Cognitive Sciences, Tsinghua University, Beijing 100084, China.
Yuchen GuoInstitute for Brain and Cognitive Sciences, Beijing National Research Center for Information Science and Technology, Tsinghua University, Beijing 100084, China.
Hengrui LiangDepartment of Thoracic Oncology and Surgery, China State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China.
Jianxing HeDepartment of Thoracic Oncology and Surgery, China State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China.
Yuerong LizhuDepartment of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China.
Yaou LiuTiantan Image Research Center, China National Clinical Research Center for Neurological Diseases, Beijing 100070, China.
Feng XuSchool of Software, Beijing National Research Center for Information Science and Technology (BNRist), Institute for Brain and Cognitive Sciences, Tsinghua University, Beijing 100084, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Radiographic images play a critical role in disease diagnosis, but accurately interpreting them requires considerable expertise and workload. Recent research has advanced artificial intelligence-based medical image analysis, but such advancements remain limited in real clinical practice where multistage diagnosis is required for fine-grained diseases. This study proposes a screening-to-subtyping (S2S) AI paradigm specifically designed for accurate radiological diagnosis of fine-grained diseases, encompassing the entire diagnostic process from initial screening to final subtyping. The S2S framework integrates information from multiple diagnostic phases, radiological viewpoints, lesion dimensions, and imaging modalities to address complex diagnostic challenges. Evaluation using a large-scale, multi-center radiography dataset of fine-grained thoracic cancer subtypes demonstrates the system's robust performance. Furthermore, this investigation offers novel insights into human-AI collaboration for diagnosing intricate fine-grained pathologies. Our results highlight the substantial clinical potential of S2S AI across varied healthcare environments and disease entities, facilitating deeper integration of artificial intelligence in radiological diagnostics.

Indexed as

artificial intelligencedeep learningdisease subtypingfine-grained diseasemediastinal neoplasmradiological diagnosis

Identifiers

PMID41142912
PMCPMC12546454

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.