Evidence map›Paper›PMID 41142908›Full record

ArticlePatterns (New York, N.Y.)2025

A consensus privacy metrics framework for synthetic data.

Lisa Pilgram, Fida Kamal Dankar, Jörg Drechsler, Mark Elliot, Josep Domingo-Ferrer, Paul Francis, Murat Kantarcioglu, Linglong Kong, Bradley Malin, Krishnamurty Muralidhar and 5 more

Abstract read
In one paragraph

Article in Patterns (New York, N.Y.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Lisa PilgramSchool of Epidemiology and Public Health, University of Ottawa, Ottawa, ON K1H 8M5, Canada.
Fida Kamal DankarCHEO Research Institute, Ottawa, ON K1H 8L1, Canada.
Jörg DrechslerDepartment for Statistical Methods, Institute for Employment Research, Nuernberg, 90478 Bavaria, Germany.
Mark ElliotThe Cathie Marsh Institute Research, School of Social Sciences, University of Manchester, M13 9PL Manchester, UK.
Josep Domingo-FerrerDepartment of Computer Engineering and Mathematics, Universitat Rovira i Virgili, Tarragona, 43007 Catalonia, Spain.
Paul FrancisMax Planck Institute for Software Systems, Kaiserslautern, 67663 Rhineland-Palatinate, Germany.
Murat KantarciogluDepartment of Computer Science, Virginia Tech, Blacksburg, VA 24060, USA.
Linglong KongDepartment of Mathematical and Statistical Sciences, University of Alberta, Edmonton, AB T6G 2R3, Canada.
Bradley MalinDepartment of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN 37203, USA.
Krishnamurty MuralidharDepartment of Marketing and Supply Chain Management, Price College of Business, University of Oklahoma, Norman, OK 73019, USA.
Puja MylesMedicines and Healthcare Products Regulatory Agency, SW1W 9SZ London, UK.
Fabian PrasserBerlin Institute of Health at Charité - Universitätsmedizin Berlin, Medical Informatics Group, 10117 Berlin, Germany.
Jean Louis RaisaroBiomedical Data Science Center, University Hospital Lausanne, 1011 Lausanne, Switzerland.
Chao YanDepartment of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN 37203, USA.
Khaled El EmamSchool of Epidemiology and Public Health, University of Ottawa, Ottawa, ON K1H 8M5, Canada.

Funding

Ethics Core (FABRIC)U54HG012510 · NHGRI · YALE UNIVERSITY · PI MALIN, BRADLEY A. · 2022 to 2025
$11.2M
Genetic Privacy and Identity in Community Settings - GetPreCiSeRM1HG009034 · NHGRI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI CLAYTON, ELLEN WRIGHT, MALIN, BRADLEY A. · 2016 to 2024
$8.3M
Generative AI for synthetic data: A framework to expand health data reach for research and ensure algorithmic fairnessK99LM014428 · NLM · VANDERBILT UNIVERSITY MEDICAL CENTER · PI YAN, CHAO · 2024 to 2025
$174k
NHGRI NIH HHS RM1 HG009034NHGRI NIH HHS U54 HG012510NLM NIH HHS K99 LM014428
6 · The paper itself

Abstract

Synthetic data generation is a promising approach for sharing data for secondary purposes in sensitive sectors. However, to meet ethical standards and legislative requirements, it is necessary to demonstrate that the privacy of the individuals upon which the synthetic records are based is adequately protected. Through an expert consensus process, we developed a framework for privacy evaluation in synthetic data. The most commonly used metrics measure similarity between real and synthetic data and are assumed to capture identity disclosure. Our findings indicate that they lack precise interpretation and should be avoided. There was consensus on the importance of membership and attribute disclosure, both of which involve inferring personal information. The framework provides recommendations to effectively measure these types of disclosures, which also apply to differentially private synthetic data if the privacy budget is not close to zero. We further present future research opportunities to support widespread adoption of synthetic data.

Indexed as

attribute disclosuredata sharinggenerative artificial intelligenceidentity disclosuremembership disclosureprivacysynthetic data

Identifiers

PMID41142908
PMCPMC12546437

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.