Evidence map›Paper›PMID 41142902›Full record

ReviewPatterns (New York, N.Y.)2025

The cost of unmodeled biological complexity in artificial neural networks.

Antonio Bikić, Corinna Kaspar, Wolfram H P Pernice

Abstract readReview
In one paragraph

Review in Patterns (New York, N.Y.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Antonio BikićDepartment for Physics and Astronomy, Kirchhoff Institute for Physics, Heidelberg University, Heidelberg, Germany.
Corinna KasparDepartment of Physics, Institute of Physics, University of Münster, Münster, Germany.
Wolfram H P PerniceDepartment of Physics, CeNTech - Center for Nanotechnology, University of Münster, Münster, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We propose the theories of pragmatism and functionalism to differentiate between artificial neural networks (ANNs) and biological neural networks (BNNs). While ANNs emulate some cell structures and function approximation mechanisms, questions remain about their ability to emulate intelligent behavior observed in BNNs. We propose that relying solely on biological structures suitable for function approximation may overlook pivotal aspects of ANNs' development, limiting their potential to emulate robust intelligence. Specifically, we investigate the role of ion channels in biological neurons and the randomness they introduce. This randomness seems to be vital for spike generation, although it is not directly related to function approximation. We conclude that structures, which do not directly contribute to function approximation, play a significant role in controlled activity, such as behavior, and should be integrated more into the controlled activity of artificial systems.

Indexed as

artificial intelligenceartificial neural networksartificial neuronfunctionalismion channelsneuromorphic computingoptimizationpragmatismrandomness

Identifiers

PMID41142902
PMCPMC12546654

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.