Evidence map›Paper›PMID 41142896›Full record

ArticleSleep advances : a journal of the Sleep Research Society2025

Breakdown of thalamocortical connectivity under sleep deprivation: implications for cognitive arousal and transient sleep states.

David Negelspach, Alisa Huskey, Kathryn Kennedy, Jungwon Cha, Jason Katz, William D S Killgore

Abstract read
In one paragraph

Article in Sleep advances : a journal of the Sleep Research Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

David NegelspachUniversity of Arizona, College of Medicine, Department of Psychiatry, Tucson, AZ, Pima County, United States.ORCID https://orcid.org/0009-0005-1144-0743
Alisa HuskeyUniversity of Arizona, College of Medicine, Department of Psychiatry, Tucson, AZ, Pima County, United States.
Kathryn KennedyUniversity of Arizona, College of Medicine, Department of Psychiatry, Tucson, AZ, Pima County, United States.
Jungwon ChaUniversity of Arizona, College of Medicine, Department of Psychiatry, Tucson, AZ, Pima County, United States.
Jason KatzUniversity of Arizona, College of Medicine, Department of Psychiatry, Tucson, AZ, Pima County, United States.
William D S KillgoreUniversity of Arizona, College of Medicine, Department of Psychiatry, Tucson, AZ, Pima County, United States.ORCID https://orcid.org/0000-0002-5328-0208

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Functional neuroimaging conducted at regular intervals throughout sleep deprivation reveals key thalamocortical connectivity changes that characterize the transition from a well-rested to a sleep-deprived state. Decreased thalamic connectivity is distributed across sensorimotor, visual, and limbic networks, including subcortical structures such as the parahippocampal gyrus and hippocampus. Associated changes in globally efficiency closely track group-level deficits in psychomotor vigilance, suggesting that thalamic-cortical interactions play a role in wake maintenance during sleep deprivation. These patterns of connectivity disruptions may reflect transient, sleep-like states arising from unstable wakefulness. Causal modeling indicates impaired self-inhibition within the thalamus is a dominant feature of sleep deprivation, which likely contributes to wake-state instability and attentional lapses.

Indexed as

functional brain neuroimagingfunctional connectivitysleep deprivation

Identifiers

PMID41142896
PMCPMC12551454

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.