Evidence map›Paper›PMID 41142824›Full record

ArticleFrontiers in immunology2025

IFNγ-mediated suppression of alternative NF-κB in tumor-resident myeloid cells promotes selective recruitment of cytotoxic but not regulatory T cells.

Adam Brinkman, Ravikumar Muthuswamy, Bowen Dong, Robert P Edwards, Pawel Kalinski

Abstract read
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Adam BrinkmanDepartment of Immunology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, United States.
Ravikumar MuthuswamyDepartment of Surgery, University of Pittsburgh Hillman Cancer Center, Pittsburgh, PA, United States.
Bowen DongDepartment of Immunology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, United States.
Robert P EdwardsDepartment of OBGYN, Magee Women's Hospital and Research Institute, Pittsburgh, PA, United States.
Pawel KalinskiDepartment of Immunology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, United States.

Funding

MULTIDISCIPLINARY APPROACHES TUMOR IMMUNOLOGYT32CA085183 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI Scott I. Abrams · 2001 to 2026
$3.1M
NCI NIH HHS T32 CA085183
6 · The paper itself

Abstract

Immunotherapy is currently effective in less than half of patients with solid tumors, and most responders develop secondary progression. High infiltration of the tumor microenvironment (TME) with CD8

Indexed as

Interferon-gammaMyeloid CellsNF-kappa BOvarian NeoplasmsT-Lymphocytes, CytotoxicT-Lymphocytes, RegulatoryCell Line, TumorChemokine CCL22FemaleHumansLymphocyte ActivationLymphocytes, Tumor-InfiltratingSignal TransductionTumor MicroenvironmentCCL22 protein, humanChemokine CCL22Interferon-gammaNF-kappa Balternative NF-κBchemokinesCTLsinterferon gamma (IFNγ)myeloid cellsTregs (regulatory T cells)tumor micro environment (TME)

Identifiers

PMID41142824
PMCPMC12546131

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.