Evidence map›Paper›PMID 41142795›Full record

ArticleFrontiers in immunology2025

Prognostic genes related to mitochondrial dynamics and mitophagy in diffuse large B-cell lymphoma are identified and validated using an integrated analysis of bulk and single-cell RNA sequencing.

Qingjiao Chen, Mingui Chen, Jizhen Wang, Jinfeng Dong, Apeng Yang, Xiaolin Zhu, Qiaoxian Lin, Jinlong Huang, Guilan Lai, Meihong Zheng and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Qingjiao Chen *Department of Hematology, The First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian, China.
Mingui Chen *Hongshan Town Community Healthcare Service Center, Fuzhou, Fujian, China.
Jizhen WangDepartment of Hematology, The First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian, China.
Jinfeng DongDepartment of Hematology, The First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian, China.
Apeng YangDepartment of Hematology, The First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian, China.
Xiaolin ZhuDepartment of Hematology, The First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian, China.
Qiaoxian LinDepartment of Hematology, The First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian, China.
Jinlong HuangDepartment of Hematology, The First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian, China.
Guilan LaiDepartment of Hematology, The First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian, China.
Meihong ZhengDepartment of Hematology, The First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian, China.
Zhiyong ZengDepartment of Hematology, The First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian, China.
Junmin ChenDepartment of Hematology, The First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian, China.
Junfang LinDepartment of Hematology, The First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian, China.
Xiaoqiang ZhengDepartment of Hematology, The First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: While the link between mitochondrial homeostasis, specifically dynamics and mitophagy, and the progression of diffuse large B-cell lymphoma (DLBCL) has been suggested, their prognostic significance and functional networks remain unclear. This study aimed to investigate the role of mitochondrial dynamics-related genes (MDRGs) in DLBCL patient outcomes. Methods: Candidate MDGRs were identified via Weighted Gene Co-expression Network Analysis (WGCNA) and differential expression analysis using public RNA-seq data. A prognostic signature was established via LASSO-Cox regression, followed by proportional hazards assumption validation. Functional pathways, regulatory networks (including miR-1252-5p/NEAT1), and a risk-scoring model were analyzed. Model assessment included nomograms, immune cell infiltration, m6A regulator, and pharmacogenomics. Single-cell mapping was employed to characterize B-cell differentiation and spatial gene expression. Finally, the findings were validated using RT-qPCR on clinical samples. Results: Six lysosomal-enriched genes ( Conclusion:

Indexed as

Biomarkers, TumorLymphoma, Large B-Cell, DiffuseMitochondriaMitophagyFemaleGene Expression ProfilingGene Expression Regulation, NeoplasticGene Regulatory NetworksHumansMaleMiddle AgedPrognosisSequence Analysis, RNASingle-Cell AnalysisTumor MicroenvironmentBiomarkers, Tumordiffuse large B-cell lymphomamitochondrial dynamicsmitochondrial homeostasis signaturemitophagysingle-cell prognostic stratification

Identifiers

PMID41142795
PMCPMC12546034

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.