ArticleFrontiers in immunology2025
Immunotherapy versus chemotherapy as adjuvant therapy for resected MSI-H/dMMR colorectal cancer: real-world evidence informing precision strategies.
Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Immunotherapy has demonstrated unique advantages in MSI-H/dMMR colorectal cancer (CRC) for its later-line, first-line in metastatic status, and neoadjuvant therapy. However, evidence regarding its value in postoperative adjuvant therapy remains limited. Methods: We retrospectively analyzed 261 stage II/III MSI-H/dMMR CRC patients who underwent radical resection with over 2 years of follow-up. Disease-free survival (DFS) curves were used to compare prognoses under different postoperative strategies, and factors associated with recurrence were investigated. Results: The patients cohort (mean age 55.3, range 19-86 years and male for 56.3%) had a median follow-up of 30 (range 24-45) months. Recurrence occurred in 18 patients (6.9%), with an overall DFS rate of 93.1% during follow-up period. Overall, postoperative immunotherapy showed non-significant DFS advantage over watchful waiting (WW) (HR = 0.19, 95%CI: 0.03-1.39, P = 0.101), but it demonstrated statistically superior DFS compared to chemotherapy (HR = 0.26, 95%CI: 0.08-0.89, P = 0.033). Subgroup analyses revealed: 1) For patients achieving pathologic complete response after neoadjuvant therapy, postoperative WW and immunotherapy were equivalent (both DFS 100%); 2) For Stage II, WW and immunotherapy showed comparable DFS (HR = 0.21, 95%CI: 0.003-13.04, P = 0.463). 3) For Stage III, immunotherapy showed a trend toward superior DFS versus chemotherapy, though statistical significance was not reached (HR = 0.28, 95%CI: 0.04-1.96, P = 0.204), and both outperformed WW (HR = 0.05, 95%CI: 0.004-0.54, P = 0.014 and HR = 0.34, 95%CI: 0.05-2.17, P = 0.113, respectively). Factors significantly associated with recurrence included Lynch-negative (P = 0.02) and perineural invasion (P = 0.014). Conclusions: MSI-H/dMMR CRC exhibits excellent prognosis after radical surgery. Postoperative WW remains the preferred strategy for Stage II patients, While patients with stage III requires intensive adjuvant therapy, and immunotherapy may surpass conventional chemotherapy recommended by the current guidelines.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.