ArticleThe Lancet regional health. Europe2025
PD-L1 inhibitors combined with chemotherapy for extensive-stage small cell lung cancer: a French nationwide cohort study.
Article in The Lancet regional health. Europe, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Immunotherapy with atezolizumab and durvalumab has significantly advanced the treatment of extended-stage small cell lung cancer (esSCLC). We aimed at studying the real-world use and comparative effectiveness and safety of these treatments. Methods: We utilised the French National Health Data System (SNDS) to include all patients treated with atezolizumab or durvalumab for esSCLC from May 1, 2019 to December 31, 2023, with follow-up until June 30, 2024. Baseline characteristics were described. Effectiveness (time to treatment discontinuation and overall survival) and safety (all-cause and cause-specific overnight hospitalisations) were assessed using Cox proportional hazards models. Findings: A total of 8612 patients were included, with 5188 initiating atezolizumab and 3424 initiating durvalumab. The mean age at inclusion was 66·2 years (standard deviation 8·7), and most patients were men (63·8%, n = 5493). The median time to treatment discontinuation was 5·4 months (95% CI, 5·3-5·5) for atezolizumab and 5·5 months (95% CI, 5·4-5·6) for durvalumab, with an adjusted hazard ratio (aHR) of 0·97 (95% CI, 0·92-1·02) for durvalumab vs. atezolizumab. The median overall survival was 11·1 months (95% CI, 10·6-11·4) for atezolizumab and 11·4 months (95% CI, 10·9-11·9) for durvalumab, with an aHR of 0·93 (95% CI, 0·88-0·98) for durvalumab vs. atezolizumab.While 61·8% (n = 5323) of patients received systemic steroids, testifying of immune-mediated side effects, no significant safety differences were observed between the groups. Interpretation: Our study found no clinically relevant differences in effectiveness or safety between atezolizumab and durvalumab for first-line esSCLC. Both treatments appearing interchangeable, treatment decision could be based on drug availability, local institutional protocols, administrative organisation, or cost considerations. Funding: None.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.