Evidence map›Paper›PMID 41142645›Full record

ArticleMed-X2025

Dysphagia assessment based on photoacoustic imaging: a pilot ex vivo and in vivo study in infant swine models.

Yanda Cheng, Chuqin Huang, Robert W Bing, Emily Zheng, Huijuan Zhang, Wenyao Xu, Christopher Mayerl, Rebecca German, Catriona M Steele, Jonathan Lovell and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Med-X, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yanda ChengDepartment of Biomedical Engineering, University at Buffalo, The State University of New York, Buffalo, NY USA.
Chuqin HuangDepartment of Biomedical Engineering, University at Buffalo, The State University of New York, Buffalo, NY USA.
Robert W BingDepartment of Biomedical Engineering, University at Buffalo, The State University of New York, Buffalo, NY USA.
Emily ZhengDepartment of Biomedical Engineering, University at Buffalo, The State University of New York, Buffalo, NY USA.
Huijuan ZhangDepartment of Biomedical Engineering, University at Buffalo, The State University of New York, Buffalo, NY USA.
Wenyao XuDepartment of Computer Science and Engineering, University at Buffalo, The State University of New York, Buffalo, NY USA.
Christopher MayerlDepartment of Anatomy and Neurobiology, Northeast Ohio Medical University, Rootstown, OH USA.
Rebecca GermanDepartment of Anatomy and Neurobiology, Northeast Ohio Medical University, Rootstown, OH USA.
Catriona M SteeleToronto Rehabilitation Institute, University Health Network, Toronto, ON Canada.
Jonathan LovellDepartment of Biomedical Engineering, University at Buffalo, The State University of New York, Buffalo, NY USA.
Lin ZhangDepartment of Biomedical Engineering, University at Buffalo, The State University of New York, Buffalo, NY USA.
Jun XiaDepartment of Biomedical Engineering, University at Buffalo, The State University of New York, Buffalo, NY USA.ORCID 0000-0002-9864-7835

Funding

Establishing Reference Values and Clinical Decision Points for Quantitative Videofluoroscopic Measures of SwallowingR01AG077481 · NIA · UNIVERSITY HEALTH NETWORK · PI Emily Kate Plowman, Catriona Margaret Steele · 2022 to 2026
$4.3M
Tongue-pressure timing for liquid flow detection and control in swallowingR01DC011020 · NIDCD · UNIVERSITY HEALTH NETWORK · PI STEELE, CATRIONA MARGARET · 2010 to 2020
$2.9M
NIA NIH HHS R01 AG077481NIDCD NIH HHS R01 DC011020
6 · The paper itself

Abstract

Swallowing impairments, such as dysphagia, pose significant health risks, including aspiration pneumonia, especially in vulnerable populations like infants and the elderly. Traditional diagnostic methods like videofluoroscopy and Fiberoptic Endoscopic Evaluation of Swallowing have limitations, including radiation exposure and discomfort. This study explores the potential of photoacoustic imaging as a non-invasive alternative for detecting swallowing events. Utilizing a 10 mg/mL charcoal solution as a contrast agent, we conducted both ex-vivo and in-vivo experiments using pig models. The ex-vivo tests on pig cadavers validated the system's ability in detecting charcoal flow in the airway. Subsequent in-vivo experiments on live pigs, conducted with synchronized videofluoroscopy, demonstrated photoacoustic's potential in seeing the same structure as videofluoroscopy. Our preliminary investigation indicates that photoacoustic imaging could offer a safer, more accurate method for dysphagia assessment, particularly in pediatric settings. Graphical Abstract: Supplementary Information: The online version contains supplementary material available at 10.1007/s44258-025-00062-6.

Indexed as

AspirationDysphagiaPhotoacoustic imagingSwallow assessmentUltrasoundVideofluoroscopy

Identifiers

PMID41142645
PMCPMC12546401

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.