ArticleFrontiers in oncology2025
Somatic gene variation profiles in geriatric and adult malignant melanoma patients.
Article in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Skin cancer is a highly heterogeneous disease affecting substantial geriatric individuals. Therefore, understanding gene variants and their presence in geriatric and adult skin cancer patient groups is valuable for the improvement of healthcare policies. The somatic variation profile in geriatric patients diagnosed with malignant melanoma (MM) was examined retrospectively by comparing them to the younger cases to reveal the clinical importance of the panel tests. Methods: The study included all adult MM patients referred to Molecular Pathology Laboratory from Oncology Clinic between 2019 and 2023. The patients ( Results: Among the study cohort, 58 (56.31%) were male, 45 (43.69%) were female, and also 55 were in the geriatric age group, 48 were in the adult group with an overall mean age of 63.30 years. The most commonly encountered pathogenic variants in the geriatric MM group were Conclusions: Delineating the distribution of somatic variations in geriatric MM cases holds significant importance in the development of healthcare policies. These data are the first reported findings from Türkiye.
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