Evidence map›Paper›PMID 41142588›Full record

ArticleBJA open2025

Intraoperative hypotension and postoperative delirium among older high-risk patients undergoing major noncardiac surgery: a retrospective single-centre cohort study.

Inaame Ettoumi, Daniel Pearce, Theodora Wingert, Amelie Delaporte, Brenton Alexander, Ravi Pal, Jason Tang, Nancy M Boulos, Yann Gricourt, Janice Boktor and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BJA open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Inaame EttoumiDepartment of Anesthesiology, Université Paris-Saclay, Hôpital Bicetre, Assistance Publique Hôpitaux de Paris, Le Kremlin Bicêtre, France.
Daniel PearceDepartment of Anesthesiology & Perioperative Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Theodora WingertDepartment of Anesthesiology & Perioperative Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Amelie DelaporteDepartment of Anesthesiology & Perioperative Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Brenton AlexanderDavid Geffen School of Medicine, University of California Los Angeles, San Diego, CA, USA.
Ravi PalDepartment of Anesthesiology & Perioperative Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Jason TangDepartment of Anesthesiology & Perioperative Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Nancy M BoulosDepartment of Anesthesiology & Perioperative Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Yann GricourtDepartment of Anesthesiology & Perioperative Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Janice BoktorDepartment of Anesthesiology, University of California San Diego, La Jolla, CA, USA.
Maziar M NourianDepartment of Anesthesiology, Université Paris-Saclay, Hôpital Bicetre, Assistance Publique Hôpitaux de Paris, Le Kremlin Bicêtre, France.
Tristan GroganDepartment of Medicine Statistics Core, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Cecila CanalesDepartment of Anesthesiology & Perioperative Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Dan ColeDepartment of Anesthesiology & Perioperative Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Robert A WhittingtonDepartment of Anesthesiology & Perioperative Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Maxime CannessonDepartment of Anesthesiology & Perioperative Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Alexandre JoostenDepartment of Anesthesiology & Perioperative Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.

Funding

Personalized Risk Prediction for Prevention and Early Detection of Postoperative Failure to RescueR01EB035028 · NIBIB · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Maxime Cannesson · 2023 to 2026
$2.3M
Improving Postsurgical Cognitive Outcomes in Limited English Proficient Older Adults with a Perioperative Care Partner Program: A Pilot Pragmatic Randomized Controlled TrialK76AG088558 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Cecilia Canales · 2025 to 2026
$486k
NIA NIH HHS K76 AG088558NIBIB NIH HHS R01 EB035028NIMHD NIH HHS L32 MD017730
6 · The paper itself

Abstract

Background: Intraoperative hypotension has been associated with postoperative complications, but its relationship with postoperative delirium remains debated. Methods: This single-centre retrospective cohort study included adults (≥60 yr) with ASA physical status score of 3 or 4 undergoing major noncardiac surgery, with documented Confusion Assessment Method assessments. Patients with a history of neurosurgery, stroke, dementia, or neurocognitive disorders were excluded. The primary exposure was the cumulative duration of a mean arterial pressure <65 mm Hg (minutes). The primary outcome was postoperative delirium within 7 days, diagnosed via Confusion Assessment Method. Multivariable logistic regression was used to assess the association between intraoperative hypotension and delirium, adjusting for confounders. Results: Among 5171 patients included from 2013-2024, 632 (11.8%) developed delirium. The median (Q1-Q3) duration of surgery and time with mean arterial pressure <65 mm Hg were 281 (199-430) min and 28 (9-61) min, respectively. In models adjusted for patient characteristics and perioperative factors, intraoperative hypotension was associated with increased odds of delirium (odds ratio per 60 min, 1.12; 95% confidence interval, 1.01-1.24; Conclusions: Although intraoperative hypotension initially appeared to be associated with postoperative delirium, this association was no longer significant when accounting for temporal improvements in perioperative care. Intraoperative hypotension may represent a marker of historical practice patterns rather than an independent causal driver of delirium.

Indexed as

arterial pressureblood pressureconfusionoutcomepostoperative

Identifiers

PMID41142588
PMCPMC12550159

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.