Evidence map›Paper›PMID 41142571›Full record

ArticleFrontiers in veterinary science2025

Pseudolaric acid B induces G2/M phase arrest in canine mammary tumor cells by targeting CDK1.

Mengjuan Chen, Hui Han, Mengke Qin, Huixin Li, Qiqi Lu, Xin Huang, Qingda Meng, Shanshan Xie

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in veterinary science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Mengjuan Chen *College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, China.
Hui Han *College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, China.
Mengke QinCollege of Veterinary Medicine, Henan Agricultural University, Zhengzhou, China.
Huixin LiCollege of Veterinary Medicine, Henan Agricultural University, Zhengzhou, China.
Qiqi LuCollege of Veterinary Medicine, Henan Agricultural University, Zhengzhou, China.
Xin HuangCollege of Veterinary Medicine, Henan Agricultural University, Zhengzhou, China.
Qingda MengCollege of Veterinary Medicine, Henan Agricultural University, Zhengzhou, China.
Shanshan XieCollege of Veterinary Medicine, Henan Agricultural University, Zhengzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Current management of canine mammary tumors (CMTs) remains reliant on surgical resection and chemotherapy. However, these strategies are often limited by high recurrence rates and systemic toxicity. Addressing these limitations requires urgent development of safer and more effective therapeutics. Pseudolaric acid B (PAB), a bioactive compound extracted from the roots of the Methods and results: Discussion: These findings not only expand the translational applicability of PAB in veterinary oncology but also identify CDK1 as a potential therapeutic vulnerability for combinatorial treatment strategies in CMTs.

Indexed as

canine mammary tumorCDK1cell apoptosiscell cyclePseudolaric acid B

Identifiers

PMID41142571
PMCPMC12547503

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.