Evidence map›Paper›PMID 41142541›Full record

ArticleGland surgery2025

Predictive factors for re-recurrence in papillary thyroid carcinoma following reoperation: a retrospective analysis.

Sang Chun Park, Sang Ho Jo, Hee Won Ryu, Hye Yun Ma, Yong Bin Kwon, Yong Min Na, Jin Seong Cho, Min Ho Park, Su Woong Yoo, Seong Young Kwon and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gland surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Sang Chun ParkDepartment of Surgery, Chonnam National University Hwasun Hospital, Jeollanam-do, South Korea.ORCID https://orcid.org/0000-0002-6792-2523
Sang Ho JoDepartment of Surgery, Chonnam National University Hwasun Hospital, Jeollanam-do, South Korea.
Hee Won RyuDepartment of Surgery, Chonnam National University Hwasun Hospital, Jeollanam-do, South Korea.
Hye Yun MaDepartment of Surgery, Chonnam National University Hwasun Hospital, Jeollanam-do, South Korea.
Yong Bin KwonDepartment of Surgery, Chonnam National University Hospital, Gwangju, South Korea.
Yong Min NaDepartment of Surgery, Chonnam National University Medical School, Gwangju, South Korea.
Jin Seong ChoDepartment of Surgery, Chonnam National University Medical School, Gwangju, South Korea.
Min Ho ParkDepartment of Surgery, Chonnam National University Medical School, Gwangju, South Korea.
Su Woong YooDepartment of Nuclear Medicine, Chonnam National University Medical School, Gwangju, South Korea.
Seong Young KwonDepartment of Nuclear Medicine, Chonnam National University Medical School, Gwangju, South Korea.
Jee Hee YoonDepartment of Internal Medicine, Chonnam National University Medical School, Gwangju, South Korea.
Ji Yong ParkDepartment of Internal Medicine, Chonnam National University Medical School, Gwangju, South Korea.
Hee Kyung KimDepartment of Internal Medicine, Chonnam National University Medical School, Gwangju, South Korea.
Young Jae RyuDepartment of Surgery, Chonnam National University Medical School, Gwangju, South Korea.ORCID https://orcid.org/0000-0001-7302-8109

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Papillary thyroid carcinoma (PTC) generally has a favorable prognosis; however, recurrence occurs in up to 30% of cases following initial management. Re-recurrence presents additional clinical challenges, making it crucial to distinguish between persistent disease and true recurrence in order to optimize management strategies and improve patient outcomes. Despite its significance, studies focusing on the risk factors for re-recurrence in PTC are limited. This study aimed to identify the risk factors for re-recurrence in PTC patients who underwent total thyroidectomy and central neck dissection, with or without lateral neck dissection, as the initial operation. Methods: A retrospective review was conducted on the medical records of 158 PTC patients who underwent reoperation for recurrence at a single institution between February 2006 and October 2020. Predictive factors for re-recurrence were identified using Cox proportional hazards models and Kaplan-Meier survival analyses. Results: During a median follow-up of 101.3 months after reoperation, re-recurrence occurred in 27 (17.1%) patients. Univariate analysis revealed that initial T4 stage (P=0.006), initial lymph node ratio >0.7 (P=0.049), and unstimulated thyroglobulin (Tg) ≥1 ng/mL (P=0.02) were significantly associated with worse recurrence-free survival after reoperation. In multivariate analysis, T4a stage [ Conclusions: Short-term follow-up with appropriate imaging modalities is necessary for patients with T4a stage disease and for those who had elevated Tg levels after the first reoperation due to PTC.

Indexed as

Papillary thyroid carcinoma (PTC)reoperationre-recurrence

Identifiers

PMID41142541
PMCPMC12552543

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.