ArticleGland surgery2025
Diverging spatiotemporal trajectories of thyroid cancer incidence and mortality in reproductive-age women: a socio-demographic index stratified analysis of GBD 2021 data.
Article in Gland surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed.
- Article
- Tracking three decades of type 1 diabetes-related chronic kidney disease in East Asia: Burden, age-sex patterns, and quality of care index.Journal of diabetes investigation · 2026Article
- Spatial-temporal epidemiological characteristics of thyroid cancer mortality in China cancer registration areas: analysis based on multiple models.Frontiers in oncology · 2026Article
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7 authors.
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Abstract
Background: Thyroid cancer ranks among the most rapidly increasing endocrine malignancies worldwide, with a particularly disproportionate health burden observed in women of reproductive age. This study aimed to comprehensively assess the global, regional, and national trends in thyroid cancer burden among women aged 15-49 years from 1990 to 2021, and to explore disparities by socio-demographic index (SDI) level. Methods: Utilizing data from the Global Burden of Disease (GBD) Study 2021, this study assessed the burden of thyroid cancer among women aged 15-49 between 1990 and 2021 and examined its association with SDI levels. Key indicators-including age-standardized incidence rate (ASIR), mortality rate (ASMR), and disability-adjusted life years rate (ASDR)-were analyzed alongside estimated annual percentage change (EAPC), frontier analysis, and a Bayesian age-period-cohort (BAPC) model to evaluate trends and disparities across 204 countries and territories. Results: Globally, the ASIR of thyroid cancer among women of reproductive age increased from 2.86 to 3.83 per 100,000 population (EAPC =1.03), while ASMR and ASDR declined to 0.58 per 100,000 (EAPC =-0.58) and 16.70 per 100,000 (EAPC =-0.45), respectively. High-SDI regions exhibited a "high incidence-low mortality" pattern (ASIR =5.60/100,000; ASMR =0.45/100,000), whereas certain low-SDI regions-such as Sub-Saharan Africa-experienced a concerning increase in mortality (EAPC =0.95). Projections suggest that by 2050, the global incidence will continue to rise to 4.00 per 100,000, while mortality rates will remain largely unchanged. Inequality analysis revealed that, although the concentration index in high-SDI countries declined to 0.17 compared to 1990, disparities in disease burden remain substantial. Conclusions: Socioeconomic disparities underpin the global heterogeneity in thyroid cancer burden. While high-SDI countries should focus on optimizing screening protocols to mitigate overdiagnosis, low-SDI regions urgently require enhanced diagnostic and therapeutic resource allocation. These findings provide crucial evidence to support the development of region-specific public health interventions.
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