Evidence map›Paper›PMID 41142518›Full record

ArticleGastro hep advances2025

Halting Hypercaloric Feeding in Liver Chimeric Mice Rapidly Resolves Human Hepatocyte Steatosis.

Aditya Upadhyay, Mohammad Kabbani, Vijay Soni, Chenhui Zou, Corrine Quirk, Yichen Zhou, Luana Barbosa, Alireza Ramandi, Georgios Dangas, James M Jordan and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gastro hep advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Aditya UpadhyayDivision of Gastroenterology and Hepatology, Weill Cornell Medicine, New York, New York.
Mohammad KabbaniLaboratory of Virology and Infectious Disease, The Rockefeller University, New York, New York.
Vijay SoniDivision of Infectious Diseases, Weill Department of Medicine, Weill Cornell Medicine, New York, New York.
Chenhui ZouDivision of Gastroenterology and Hepatology, Weill Cornell Medicine, New York, New York.
Corrine QuirkLaboratory of Virology and Infectious Disease, The Rockefeller University, New York, New York.
Yichen ZhouDivision of Gastroenterology and Hepatology, Weill Cornell Medicine, New York, New York.
Luana BarbosaDivision of Gastroenterology and Hepatology, Weill Cornell Medicine, New York, New York.
Alireza RamandiDivision of Gastroenterology and Hepatology, Weill Cornell Medicine, New York, New York.
Georgios DangasLaboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University, Atlanta, Georgia.
James M JordanDivision of Gastroenterology and Hepatology, Weill Cornell Medicine, New York, New York.
Maha MaalikiDepartment of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany.
Luis ChiribogaDepartment of Pathology, NYU Grossman School of Medicine, New York, New York.
Baran ErsoyDivision of Gastroenterology and Hepatology, Weill Cornell Medicine, New York, New York.
Björn HartlebenDepartment of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany.
Clifton G FulmerRobert J. Tomsich Pathology and Laboratory Medicine Institute, The Cleveland Clinic, Cleveland, Ohio.
Eleftherios MichailidisLaboratory of Virology and Infectious Disease, The Rockefeller University, New York, New York.
Ype P de JongDivision of Gastroenterology and Hepatology, Weill Cornell Medicine, New York, New York.

Funding

Enhancing immune regulation in gene therapy for hemophiliaR01HL131093 · NHLBI · UNIVERSITY OF FLORIDA · PI Ype Peter De Jong, Roland W. Herzog · 2016 to 2026
$7.2M
Modeling alcohol toxicity in human hepatocytesR01AA027327 · NIAAA · WEILL MEDICAL COLL OF CORNELL UNIV · PI DE JONG, YPE PETER · 2019 to 2023
$1.9M
NHLBI NIH HHS R01 HL131093NIAAA NIH HHS R01 AA027327
6 · The paper itself

Abstract

Background and Aims: Hepatocyte steatosis in metabolic dysfunction-associated steatotic liver disease can change quickly based on the types and amounts of calories consumed. This study investigates how dietary changes affect steatosis resolution in human hepatocytes and whether patatin-like phospholipase domain-containing 3 (PNPLA3) genetic variants influence this process. Methods: Chimeric mice engrafted with PNPLA3 148-isoleucine variant (huFNRG Results: After discontinuing WD and 10%S, steatosis in huFNRG Conclusion: PNPLA3 3 148-isoleucine variant human hepatocytes in chimeric mice rapidly resolve steatosis with a gradual improvement in steatohepatitis activity, which is delayed in PNPLA3-148M hepatocytes. This supports a model in which altered lipid mobilization in PNPLA3-148M hepatocytes contributes to more active steatohepatitis.

Indexed as

Humanized miceLipolysisMASHXenograft

Identifiers

PMID41142518
PMCPMC12547900

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.