ArticleSAGE open medical case reports2025
A probable case of metamizole-induced neutropaenia presenting 10 days after drug discontinuation.
Article in SAGE open medical case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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3 authors.
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Abstract
Metamizole (dipyrone) is a non-opioid analgesic and antipyretic agent belonging to the pyrazolone class. While it is widely used in many countries due to its favourable safety profile compared to non-steroidal anti-inflammatory drugs and opioids, its use has been associated with rare but potentially life-threatening haematologic adverse effects, including neutropaenia and agranulocytosis. These complications typically occur within 6-14 days of treatment initiation but may also arise earlier or significantly later, even after discontinuation of the drug. Given that late-onset neutropaenia after metamizole discontinuation may be underdiagnosed, we present the case of a 92-year-old woman who developed transient, likely drug-induced neutropaenia 10 days later, with spontaneous haematologic recovery. The patient remained asymptomatic, with no signs of infection or evidence of inflammatory or neoplastic systemic disease.
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