Evidence map›Paper›PMID 41142424›Full record

ArticleMaterials today. Bio2025

Hematoma-inspired injectable composite hydrogels incorporating hybrid metal ion microspheres for accelerated bone regeneration.

Fan Cao, Jin-Yong Wu, Qing-Ning Wang, Jun-Jie Xiao, Zhu Chen, Ya-Wen Wang, Zhi-Guo Wang, Jia-Zhuang Xu, Zhong-Ming Li, Bai-Song Zhao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Fan CaoDepartment of Cardiovascular Surgery, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, 510080, China.
Jin-Yong WuCollege of Polymer Science and Engineering, State Key Laboratory of Advanced Polymer Materials, Sichuan University, Chengdu, 610065, China.
Qing-Ning WangDepartment of Anesthesiology, The Affiliated Panyu Central Hospital of Guangzhou Medical University, Guangzhou, 511400, China.
Jun-Jie XiaoCollege of Polymer Science and Engineering, State Key Laboratory of Advanced Polymer Materials, Sichuan University, Chengdu, 610065, China.
Zhu ChenCollege of Polymer Science and Engineering, State Key Laboratory of Advanced Polymer Materials, Sichuan University, Chengdu, 610065, China.
Ya-Wen WangCollege of Polymer Science and Engineering, State Key Laboratory of Advanced Polymer Materials, Sichuan University, Chengdu, 610065, China.
Zhi-Guo WangMedicine and Engineering Interdisciplinary Research Laboratory of Nursing & Materials, West China Hospital, Sichuan University/West China School of Nursing, Sichuan University, Chengdu, 610041, China.
Jia-Zhuang XuCollege of Polymer Science and Engineering, State Key Laboratory of Advanced Polymer Materials, Sichuan University, Chengdu, 610065, China.
Zhong-Ming LiCollege of Polymer Science and Engineering, State Key Laboratory of Advanced Polymer Materials, Sichuan University, Chengdu, 610065, China.
Bai-Song ZhaoDepartment of Anesthesiology, Zhujiang Hospital, Southern Medical University, Guangzhou, 510280, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Injectable hydrogels emerge as a particularly attractive candidate in bone tissue engineering, due to their minimally invasive administration and conformal filling for irregular bone defects. However, they still lack sufficient osteoinductive activities for effective bone repair. Herein, we engineer a hematoma-inspired injectable composite hydrogel consisting of polylactide microspheres encapsulated with magnesium oxide and strontium oxide and the alginate hydrogel crosslinked by slow release of Ca

Indexed as

Bone defectsBone regenerationInjectable hydrogelOsteogenic microspheresSynergistic effect

Identifiers

PMID41142424
PMCPMC12547220

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.