Ultrasound-responsive drug-carrying microbubbles combined with piezoelectric porous titanium scaffolds for the treatment of infected bone defects.

Infected bone defects are a challenging issue in clinical orthopedics. Traditional scaffolds are prone to bacterial adhesion, colonization, and biofilm formation under infected conditions, making infection difficult to control. Additionally, severe infections can lead to tissue cell necrosis, hindering the bone repair process. In recent years, advancements in materials science and biomedical technology have driven the development of porous titanium alloy scaffolds that combine infection control with osteogenic functionality. By integrating antimicrobial properties with osteogenic potential, these scaffolds hold promise to overcome the limitations of traditional treatments and achieve early repair of infectious bone defects. Therefore, developing a porous titanium alloy scaffold that can effectively control infection and promote bone tissue regeneration under infected conditions is of significant importance for the clinical treatment of infectious bone defects. This study aims to explore the design and preparation of a dual-functional porous titanium alloy scaffold with antibacterial and bone repair capabilities, and to validate its application efficacy in infectious bone defects, with the goal of providing a more efficient and safer solution for clinical treatment.