Evidence map›Paper›PMID 41142419›Full record

ArticleMaterials today. Bio2025

Biodegradable Cu-based sonozymes for tumor-specific cuproptosis-enhanced sono-immunotherapy through activating cGAS-STING pathway and sensitizing immune checkpoint blockade.

Yue Wu, Shangwei Xu, Jinming Cai, Jinyan Hu, Dengyu Pan, Bijiang Geng, Wen Gao, Yun Wu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yue WuDepartment of Thoracic Surgery, Huadong Hospital, Fudan University, Shanghai, 200040, China.
Shangwei XuDepartment of Thoracic Surgery, Huadong Hospital, Fudan University, Shanghai, 200040, China.
Jinming CaiSchool of Environmental and Chemical Engineering, Shanghai University, Shanghai, 200444, China.
Jinyan HuSchool of Environmental and Chemical Engineering, Shanghai University, Shanghai, 200444, China.
Dengyu PanSchool of Environmental and Chemical Engineering, Shanghai University, Shanghai, 200444, China.
Bijiang GengSchool of Environmental and Chemical Engineering, Shanghai University, Shanghai, 200444, China.
Wen GaoDepartment of Thoracic Surgery, Huadong Hospital, Fudan University, Shanghai, 200040, China.
Yun WuDepartment of Thoracic Surgery, Huadong Hospital, Fudan University, Shanghai, 200040, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Promoting the maturation of dendritic cells (DCs) is crucial for effectively activating the adaptive immune response. Nevertheless, DC maturation and subsequent antigen presentation were impeded by the immunosuppressive tumor microenvironments (TME). Herein, a cascade amplification strategy for the activation of antitumor immune response is reported for the first time based on a biodegradable Cu-based sonozyme, which integrates ROS-mediated immunogenic cell death (ICD), immune checkpoint blockade (ICB), cuproptosis, and cGAS-STING activation. An in-situ phosphating strategy was employed to synthesize Cu

Indexed as

cGAS-STINGCu3PCuproptosisImmunotherapySonodynamic therapy

Identifiers

PMID41142419
PMCPMC12550172

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.