ArticleChemical science2025
Reprogramming chemically induced dimerization systems with genetically encoded nanobodies.
Article in Chemical science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Engineering viral protease-operated nanobodies for programmable and orthogonal control of protein function.Nature communications · 2026Article
- AI-GuidedJournal of the American Chemical Society · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Chemically induced proximity (CIP) systems harness small molecules to control protein-protein interactions, thereby enabling remote control over physiological processes and advancing the development of smart and personalized therapies. While substantial efforts have focused on developing new chemical inducers for tailored CIP applications, repurposing established systems to confer novel functions remains a highly cost-effective and efficient strategy. In this study, we employed genetically encoded nanobodies to overcome key bottlenecks of two widely used CIP systems in specific biological contexts. By incorporating the bivalent COSMO module and UniRapR into an anti-mCherry nanobody, we reprogrammed the homodimeric COSMO system into a caffeine-inducible heterodimerization system and transformed the classic rapamycin-dependent ON switch into an OFF switch, thereby conferring new functionality of the existing chemogenetic toolkit and expanding the repertoire of CIP technologies.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.