ArticleMolecular therapy. Nucleic acids2025
Infection-sensing minigenome as a novel therapeutic approach against Ebola virus.
Article in Molecular therapy. Nucleic acids, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
We describe here a molecular therapy that uses the virus's own proteins to combat itself. In this approach, infection-sensing RNAs encoding therapeutic genes are flanked by viral promoters and packaging signals in negative-sense orientation. These therapeutic minigenome RNAs do not express the transgene and remain silent in the absence of a viral infection. In contrast, if the cell is infected, the virus acts as a helper virus, providing viral proteins
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