ArticleEndoscopy international open2025
Diagnostic accuracy and interobserver agreement for prediction of gastric preneoplastic lesions with fourth-generation endocytoscopy: Pilot study.
Article in Endoscopy international open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and study aims: Early detection of gastric preneoplastic lesions (GPL) is essential to prevent gastric cancer. Endocytoscopy may improve optical diagnosis through in vivo histologic assessment of mucosa. We assessed diagnostic performance of endocytoscopy and interobserver agreement for GPL diagnosis compared with reference histopathology. Patients and methods: Eighty gastric areas (36 antrum, 44 corpus) from 25 prospectively recruited patients were assessed by endocytoscopy and classified as non-preneoplastic, preneoplastic, or dysplastic/neoplastic by an expert endoscopist. Targeted biopsies from each area served for histopathological assessment. High-quality images/videos were recorded for independent review by three additional observers (1 expert, 2 non-experts), blinded to endoscopic and histological findings. Results: Histologically, 25 gastric areas (31.3%) showed GPL, 14 (17.5%) atrophic gastritis, and 11 (13.8%) intestinal metaplasia. Gastric cancer was found in three cases (3.8%). Combined sensitivity, specificity, and accuracy for endocytoscopic diagnosis of GPL or dysplasia were 89.3%, 94.2%, and 92.5% among expert endocytoscopists and 85.7%, 68.3%, and 74.4%, among non-experts, respectively. Interobserver agreement was substantial (κ-value 0.79) between experts and fair (κ-value 0.30) between non-experts. Conclusions: New-generation endocytoscopy has potential to identify GPL with high diagnostic accuracy, reliability, and reproducibility. Training and clinical experience with endocytoscopy are required to maximize diagnostic performance.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.