ArticleFrontiers in pharmacology2025
Remifentanil reduces post-induction hypotension compared to fentanyl in thoracoscopic esophagectomy: a retrospective cohort study.
Article in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- The quercetin-serotonin transporter (SERT) connection: a new hope for depression therapy?Psychopharmacology · 2026Review
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7 authors.
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Abstract
Background: Post-induction hypotension (PIH) is a common complication associated with anesthesia, particularly in high-risk groups, such as elderly, malnourished patients with multiple comorbidities undergoing thoracoscopic esophagectomy. The selection of induction agents plays a significant role in influencing hemodynamic stability. However, there is a lack of comprehensive comparative data regarding the impact of different opioid agents on PIH. Methods: This retrospective cohort study included 289 patients undergoing thoracoscopic esophagectomy, who received etomidate combined with either fentanyl (Fentanyl group) or remifentanil (Remifentanil group) for anesthesia induction. A logistic regression model was used to examine the association between the induction regimen and PIH. Confounding factors were adjusted using a directed acyclic graph, and least absolute shrinkage and selection operator (LASSO) regression was employed to select covariates, ensuring robustness of the primary outcome analysis. Hemodynamic changes in systolic blood pressure, mean arterial pressure, and heart rate during the first 15 min post-induction were analyzed using generalized estimating equations to account for correlated observations. Subgroup analyses were performed for key clinical subgroups. Results: Among 289 patients analyzed, the incidence of PIH was significantly lower in the Remifentanil group compared to the Fentanyl group (23.7% vs. 42.3%, Conclusion: Remifentanil-based general anesthesia induction reduces the risk of PIH and enhances hemodynamic stability in patients undergoing thoracoscopic esophagectomy.
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