ReviewFrontiers in pharmacology2025
Pharmacological advances of the chlorogenic acids family: current insights and future research directions.
Review in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Thermochemical Valorization of Silkworm Feeding Waste: Chemical Characterization and Biological Activities of the Pyrolysis-Derived Liquid Fraction.Antioxidants (Basel, Switzerland) · 2026Article
- Liposomes, Niosomes, Ethosomes, and Transethosomes for Curcumin and Chlorogenic Acid Delivery: Formulation Design and Dermal Performance.Antioxidants (Basel, Switzerland) · 2026Review
- The Therapeutic Architecture of Chlorogenic Acids: Molecular Mechanisms in Chronic Disease Prevention.Nutrients · 2026Review
- Water extract of Artemisia capillaris alleviates fatty liver hemorrhagic syndrome in laying hens by modulating the gut microbiota-bile acid axis.Poultry science · 2026Article
- Multitarget Antiproliferative Activity ofMolecules (Basel, Switzerland) · 2026Article
- Coffee as a polypharmacological modulator of mitochondrial health: from molecular mechanisms to translational implications.Journal of translational medicine · 2026Review
- Characterization of Spent Coffee Grounds' Polyphenol Fraction and Its Potential as a Low-Cost Tool for Bioactivity-Guided Nephroprotective Modulation of Gut-Kidney Axis and NF-κB/Nrf2/TGF-β Signaling in Hypertension-Associated Kidney Injury.Antioxidants (Basel, Switzerland) · 2026Article
- Integrated Metabolomic and Microbiome Profiling Reveals Divergent Effects of No- and High-Fat Coffee in Mice.Nutrients · 2026Article
- Recent Advances in Chlorogenic Acids for Food Preservation and Shelf-Life Extension.Antioxidants (Basel, Switzerland) · 2026Review
- A novel mechanism of chlorogenic acid against type 2 diabetes-induced diabetic retinopathy: suppressing ferroptosis via NRF2/xCT/GPX4 and STAT3 signaling.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Therapeutic potential and mechanisms of plant metabolites in endometritis: a comprehensive review.Frontiers in pharmacology · 2026Review
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Phenolic acids are considered an important source for developing natural drugs due to their extensive biological activities. The chlorogenic acids (CGAs) family is the most widely distributed botanical drug in the phenolic acid group and is also commonly found in various traditional Chinese medicine (TCM) extracts. The diverse structural variations of naturally occurring chlorogenic acids result in distinct functions and mechanisms. Recent studies have demonstrated that chlorogenic acid can reduce Aβ plaques in Alzheimer's disease model mice by 37%, indicating its neuroprotective potential. Similarly, CGAs offer protection to the cardiovascular system, gastrointestinal tract, kidneys, and liver, while additionally preventing metabolic syndrome and displaying anticancer and antimicrobial capabilities. The key signaling pathways and factors involved in these effects include PI3K/AKT, NF-κB, JNK, NLRP3, and Keap1/Nrf2. This review, for the first time, provides a comparative analysis of six typical CGAs, systematically reviewing their specific distribution characteristics in traditional Chinese medicinal metabolites, biosynthetic pathways, biological targets, and pharmacological activities. This review provides a reference for the research and rational development and utilization of CGAs.
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