Evidence map›Paper›PMID 41142222›Full record

ArticleClinical case reports2025

When Hepatitis Masks Visceral Leishmaniasis: A Case of Secondary HLH in a Low-Endemic Region.

Chernet T Mengistie, Biruk T Mengistie, Temesgen H Gebremeskel, Thomas M Muluneh, Rediet G Kebede

Abstract read
In one paragraph

Article in Clinical case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Chernet T MengistieSchool of Medicine, College of Health Sciences Addis Ababa University Addis Ababa Ethiopia.ORCID https://orcid.org/0009-0009-0061-6458
Biruk T MengistieSchool of Medicine, College of Health Sciences Addis Ababa University Addis Ababa Ethiopia.ORCID https://orcid.org/0009-0005-4647-111X
Temesgen H GebremeskelSchool of Medicine, College of Health Sciences Addis Ababa University Addis Ababa Ethiopia.ORCID https://orcid.org/0009-0005-4127-4846
Thomas M MulunehSchool of Medicine, College of Health Sciences Addis Ababa University Addis Ababa Ethiopia.
Rediet G KebedeSchool of Medicine, College of Health Sciences Addis Ababa University Addis Ababa Ethiopia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Visceral leishmaniasis (VL)-associated hemophagocytic lymphohistiocytosis (HLH) is a rare but life-threatening hyperinflammatory syndrome. Diagnosis is often challenging due to overlapping clinical features, especially in low-endemic regions, where VL is not initially suspected. Severe hepatic dysfunction can further obscure the diagnosis and complicate treatment. We report a 14-year-old male from West Gojjam, Ethiopia, presenting initially with jaundice and clinical features of acute hepatitis. Over 3 months, he developed progressive abdominal distension, fever, pancytopenia, and coagulopathy. Imaging showed hepatosplenomegaly and ascites; viral and autoimmune hepatitis were excluded. Bone marrow examination revealed

Indexed as

hemophagocytic lymphohistiocytosishepatitis‐like presentationliposomal amphotericin Bsecondary HLHvisceral leishmaniasis

Identifiers

PMID41142222
PMCPMC12547617

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.