Evidence map›Paper›PMID 41142212›Full record

ArticleResuscitation plus2025

The effect of percutaneous coronary intervention after extracorporeal cardiopulmonary resuscitation on survival for out of hospital cardiac arrest: a causal inference analysis.

Laith Alhuneafat, Thomas A Murray, Nicholas J Johnson, Cindy Hsu, Brian Grunau, Tamas Alexy, Demetris Yannopoulos, Jason Bartos, Joseph E Tonna

Abstract read
In one paragraph

Article in Resuscitation plus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Laith AlhuneafatDivision of Cardiology, Department of Medicine, University of Minnesota, Minneapolis, MN, USA.
Thomas A MurrayDivision of Biostatistics and Health Data Science, School of Public Health, University of Minnesota, Minneapolis, MN, USA.
Nicholas J JohnsonDepartment of Emergency Medicine & Division of Pulmonary, Critical Care, and Sleep Medicine, University of Washington, Seattle, WA, USA.
Cindy HsuDepartment of Emergency Medicine, University of Michigan Medicine, Ann Arbor, MI, USA.
Brian GrunauDepartments of Emergency Medicine, University of British Columbia and St. Paul's Hospital, Vancouver, BC, Canada.
Tamas AlexyDivision of Cardiology, Department of Medicine, University of Minnesota, Minneapolis, MN, USA.
Demetris YannopoulosDivision of Cardiology, Department of Medicine, University of Minnesota, Minneapolis, MN, USA.
Jason BartosDivision of Cardiology, Department of Medicine, University of Minnesota, Minneapolis, MN, USA.
Joseph E TonnaDivision of Cardiothoracic Surgery, Department of Surgery, University of Utah Health, Salt Lake City, UT 84108, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Percutaneous coronary intervention (PCI) improves survival in acute coronary syndromes and has been used in recent randomized trials of extracorporeal cardiopulmonary resuscitation (ECPR). However, the role of PCI during ECPR for out-of-hospital cardiac arrest (OHCA) remains uncertain. Methods: We analyzed adult patients with OHCA from the Extracorporeal Life Support Organization (ELSO) Registry from January 2020 to December 2022 who underwent ECPR at high-volume centers. Patients were stratified by PCI receipt. We applied propensity-score weighting to balance covariates predicting the probability of receipt of PCI including year, age, sex, race, quantitative burden of comorbidities, CPR duration prior to ECMO flow start, initial cardiac arrest rhythm, and center-level case volume. The primary outcome was survival to hospital discharge. We estimated adjusted odds ratios (aORs) using multivariable logistic regression and inverse probability weighting (IPW). Results: Among 576 adult OHCA patients who received ECPR, 138 (24.3 %) received PCI. PCI patients were more likely to arrest at home (59.4 % vs. 46.1 %; Conclusions: PCI was not associated with improved survival in adult ECPR patients. These findings highlight the need for further prospective studies to clarify the role of PCI in ECPR and identify patient populations that may benefit from this intervention.

Indexed as

ECMExtracorporeal cardiopulmonary resuscitationOut-of-hospital cardiac arrestPercutaneous coronary intervention

Identifiers

PMID41142212
PMCPMC12546681

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.