Evidence map›Paper›PMID 41142195›Full record

ArticlemicroPublication biology2025

Musculoskeletal miRNA profiling after exposure to simulated space stressors in mice.

Carly Orr, Emma Mackey, Azemat Jamshidi-Parsian, Stephanie Byrum, Rupak Pathak, Robert Griffin, Nathan S Reyna

Abstract read
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In one paragraph

Article in microPublication biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Carly Orr *Biology, Ouachita Baptist University, Arkadelphia, Arkansas, United States.
Emma Mackey *Biology, Ouachita Baptist University, Arkadelphia, Arkansas, United States.
Azemat Jamshidi-Parsian *University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States.
Stephanie Byrum *Center for Proteomics and Metabolomics, St. Jude Children's Research Hospital, Memphis, Tennessee, United States.
Rupak Pathak *Division of Radiation Health, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States.
Robert Griffin *University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States.
Nathan S Reyna *Biology, Ouachita Baptist University, Arkadelphia, Arkansas, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Prolonged spaceflight exposes astronauts to chronic irradiation and microgravity, inducing oxidative stress through the production of reactive oxygen species (ROS). This study identified two microRNAs, Mir6236 and Mir6240, that were significantly downregulated in murine skeletal muscle following simulated space conditions. Sequencing and bioinformatics analysis revealed these microRNAs likely regulate key ROS-associated genes and pathways, including FN1, EZR, TRX2, and MAP2K1. Their dysregulation suggests a role in tumor progression, underscoring the need to further investigate microRNA-mediated gene regulation under space-like conditions to better understand the long-term health risks associated with extended space travel.

Identifiers

PMID41142195
PMCPMC12547510

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.