ArticleFrontiers in neurology2025
Correlation of breathing task derived cerebrovascular reactivity with baseline CBF, OEF and CMRO
Article in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Free-Breathing Hepatic Oxygen Extraction Fraction (OEF) Mapping Using Radial GESSE.Magnetic resonance in medicine · 2026Article
- Noncontrast MRI Assessment of Oxygen Metabolism in Human Calf Muscles Using VSASL and ANN-Based GESSE.NMR in biomedicine · 2026Article
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Authors and funding
11 authors.
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Abstract
Rationale and objectives: Only a few studies examined the correlation between cerebrovascular reactivity (CVR) and other physiological parameters such as cerebral blood flow (CBF), oxygen extraction fraction (OEF) and cerebral metabolic rate of oxygen (CMRO Materials and methods: All measurement were performed at 3 T. CVR was derived from a breath-holding task. Baseline CBF was measured by pseudo-continuous arterial spin labeling. Baseline OEF was measured with a gradient-echo sampling of spin-echo pulse sequence. T1 weighted anatomical image (T1W) was measured using MPRAGE sequence. CVR was calculated using customized written programs. CBF was quantified by using ASLtbx. For OEF analysis, a feedforward artificial neural network was used. CMRO Results: Fifteen healthy volunteers and five patients with brain tumors were included. In the healthy subjects, five lobes had a positive correlation between CBF and CVR ( Conclusion: Our findings demonstrate that CVR is strongly associated with CBF and CMRO₂ at both global and regional levels in healthy brains, but not with OEF. These results provide new insight into the complex interplay between vascular reactivity, perfusion, and metabolism and underscore the potential of combined CVR-CBF-CMRO
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