ArticleFrontiers in neurology2025
Assessment of benzodiazepine dosing in status epilepticus patients in the emergency department.
Article in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Treatment adequacy outweighs treatment sequence in non-convulsive status epilepticus.Epilepsia · 2026Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Status epilepticus (SE) is a medical emergency that requires immediate care and is associated with substantial mortality and morbidity. Current guidelines recommend benzodiazepines (BZDs), regardless of the type of SE, as an initial treatment. Despite established guidelines, BZD underdosing remains common in clinical practice. This study aimed to the objective of this study was to assess BZD doses in patients administered to the ED with SE and evaluate patient outcomes in relation to BZD dosing adequacy. Methods: We conducted a single-center retrospective study of adult patients (≥18 years) who presented to the ED with SE and received BZDs from January 2021 to January 2024. Primary outcome was percent of SE patients admitted to our institution who received inadequate doses of BZDs. Secondary outcomes included ICU admission rates, need for endotracheal intubation, duration of mechanical ventilation, Glasgow Coma Scale (GCS) at discharge administration of second-line antiseizure medications, and in-hospital mortality. Demographic data, treatment details, and outcomes were collected and analyzed. Results: Among 196 adult patients included, only 17% ( Conclusion: BZD underdosing in SE management remains widespread, with only 17% of patients receiving guideline-adherent initial doses. Although our study did not demonstrate significant differences in clinical outcomes based on dosing adequacy, implementation of institution-specific protocols and focused educational initiatives on weight-based BZD administration may improve guideline adherence in SE management.
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