Evidence map›Paper›PMID 41142133›Full record

ArticleiScience2025

Targeting proBDNF in neutrophil subsets: Sepsis biomarker discovery and insights into mitochondrial hyperactivation.

Qiao Li, Yuezi Hu, Ruyi Luo, Cong Luo, Pengfei Wang, Yanjun Zhong, Shengyang He, Yanwei Luo, Ruping Dai, Zhaolan Hu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Qiao LiDepartment of Anesthesiology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Yuezi HuClinical Laboratory, The Second Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, Hunan, China.
Ruyi LuoDepartment of Anesthesiology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Cong LuoDepartment of Anesthesiology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Pengfei WangDepartment of Anesthesiology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Yanjun ZhongDepartment of Critical Care Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Shengyang HeDepartment of Pulmonary and Critical Care Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Yanwei LuoDepartment of Transfusion Medicine, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
Ruping DaiDepartment of Anesthesiology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Zhaolan HuDepartment of Anesthesiology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sepsis, characterized by dysregulated immune responses, necessitates biomarkers and therapies. We conducted a prospective multicentric observational study involving sepsis patients and control groups. The proportions and brain-derived neurotrophic factor precursor (proBDNF) expression of blood neutrophil subsets were detected, and their clinical value was evaluated via correlation analysis and receiver operating characteristic curve analysis. ProBDNF was significantly upregulated in immature neutrophils (CD16

Indexed as

Health sciencesImmunologyLaboratory medicineMedical specialtyMedicine

Identifiers

PMID41142133
PMCPMC12546784

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.