Evidence map›Paper›PMID 41142128›Full record

ArticleiScience2025

Stability and biocompatibility of hBD3 with different chiral configurations and their therapeutic efficacy in periodontitis.

Miaomiao Zhang, Can Ni, Ziqing Fan, Lingjun Li, Min Wang, Yuan Wei, Wenrong Yang, Chao Liu, Fuhua Yan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Miaomiao ZhangNanjing Stomatological Hospital, Affiliated Hospital of Medical School, Institute of Stomatology, Nanjing University, Nanjing, China.
Can NiNanjing Stomatological Hospital, Affiliated Hospital of Medical School, Institute of Stomatology, Nanjing University, Nanjing, China.
Ziqing FanNanjing Stomatological Hospital, Affiliated Hospital of Medical School, Institute of Stomatology, Nanjing University, Nanjing, China.
Lingjun LiNanjing Stomatological Hospital, Affiliated Hospital of Medical School, Institute of Stomatology, Nanjing University, Nanjing, China.
Min WangNanjing Stomatological Hospital, Affiliated Hospital of Medical School, Institute of Stomatology, Nanjing University, Nanjing, China.
Yuan WeiNanjing Stomatological Hospital, Affiliated Hospital of Medical School, Institute of Stomatology, Nanjing University, Nanjing, China.
Wenrong YangSchool of Life and Environmental Sciences, Centre for Sustainable Bioproducts, Deakin University, Waurn Ponds, VIC 3216, Australia.
Chao LiuNanjing Stomatological Hospital, Affiliated Hospital of Medical School, Institute of Stomatology, Nanjing University, Nanjing, China.
Fuhua YanNanjing Stomatological Hospital, Affiliated Hospital of Medical School, Institute of Stomatology, Nanjing University, Nanjing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Periodontitis is characterized by progressive destruction of the periodontal attachment apparatus caused by dental plaque accumulation, which can lead to tooth loosening and permanent loss. Human β-defensin 3 (hBD3) exhibits broad-spectrum antibacterial activity and exerts critical immunomodulatory functions. Modifying amino acid chirality represents a novel strategy for the development of next-generation antibacterial agents. In this study, D-hBD3 and L-hBD3 were synthesized via solid-phase peptide synthesis, with recombinant hBD3 (r-hBD3) as control, and their therapeutic efficacy was evaluated in experimental periodontitis mice. Our findings demonstrated that D-hBD3 exhibited remarkable stability, potent antibacterial activity

Indexed as

BiochemistryOral medicineOral microbiologyPeptidesTherapeutics

Identifiers

PMID41142128
PMCPMC12547225

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.