ArticleiScience2025
Extracellular vesicle derived miRNAs from plasma as promising diagnosis and prognosis biomarkers for neuroblastoma.
Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed.
- Integrated miRNA-Target Gene Analysis Reveals Complementary Molecular Biomarkers and Regulatory Networks in Pediatric Neuroblastoma.International journal of molecular sciences · 2026Article
- Conditioned Media-Derived Tumor Extracellular Vesicles: Bridging Molecular Insights and Therapeutic Applications in Oncology.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnologyReview
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neuroblastoma (NB) is the most common extracranial solid tumor in children. MYCN amplification remains a critical indicator of high-risk disease and poor prognosis. Small extracellular vesicles (sEVs) carry microRNAs (miRNAs) with promising diagnostic potential. This study identified plasma sEV-derived miRNA biomarkers for NB diagnosis and MYCN status prediction. Using miRNA-seq, we analyzed plasma sEVs from 24 patients with NB (stratified by MYCN status and risk) and 10 healthy controls. Validation was performed in an independent cohort of 87 patients with NB and 47 controls. We identified six miRNAs (miR-150-5p, miR-142-5p, miR-30b-5p, miR-320a-3p, miR-30b, and miR-342-3p) that were significantly dysregulated in patients with NB, all showing excellent diagnostic accuracy (AUC >0.8). Notably, miR-150-5p and miR-342-3p differentiated MYCN-amplified from nonamplified patients (AUC = 0.738). Functional analysis revealed involvement in key NB pathways. Our findings demonstrate that plasma sEV-derived miRNAs represent valuable noninvasive biomarkers for neuroblastoma diagnosis and risk stratification.
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Registered trials
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