Evidence map›Paper›PMID 41142112›Full record

ArticleiScience2025

Dysbiosis modulates CD8

Sangeetha Jayaraman, Shanmuga Mahalingam, Michael M Lederman, Fady Faddoul, Andre Paes da Silva, Robert Asaad, Leah P Shriver, Natarajan Bhaskaran, Elizabeth Schneider, Grace Heine and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. CD8Frontiers in immunology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Sangeetha JayaramanDepartment of Biological Sciences, School of Dental Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.
Shanmuga MahalingamDepartment of Biological Sciences, School of Dental Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.
Michael M LedermanDepartment of Medicine, Division of Infectious Diseases & HIV Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.
Fady FaddoulAdvanced Education in General Dentistry, School of Dental Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.
Andre Paes da SilvaDepartment of Periodontics, School of Dental Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.
Robert AsaadUniversity Hospitals Cleveland Medical Center AIDS Clinical Trials Unit, Cleveland, OH 44106, USA.
Leah P ShriverDepartment of Chemistry, Center for Metabolomics and Isotope Tracing, Washington University, Saint Louis, MO 63110, USA.
Natarajan BhaskaranDepartment of Biological Sciences, School of Dental Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.
Elizabeth SchneiderDepartment of Biological Sciences, School of Dental Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.
Grace HeineCenter for Global Health and Diseases, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.
Tobi TaylorCenter for Global Health and Diseases, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.
Samantha HorneCenter for Global Health and Diseases, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.
Ashley YoonCenter for Global Health and Diseases, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.
Zihan ZhuDepartment of Population & Quantitative Health Sciences, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.
Liangliang ZhangDepartment of Population & Quantitative Health Sciences, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.
Adam BurgenerCenter for Global Health and Diseases, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.
Gina LewinCenter for Global Health and Diseases, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.
Pushpa PandiyanDepartment of Biological Sciences, School of Dental Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.

Funding

Probing the role of heterogeneity in streptococcal interactionsR00DE031018 · NIDCR · CASE WESTERN RESERVE UNIVERSITY · PI LEWIN, GINA · 2022 to 2024
$859k
NIDCR NIH HHS R00 DE031018
6 · The paper itself

Abstract

Polyamines play crucial roles in modulating T lymphocyte functions. Here, we demonstrate that the oral mucosa of people living with HIV (PLWH), characterized by active polyamine metabolic pathways, exhibits significantly diminished IFN-γ expression and reduced abundance of CD8

Indexed as

Health sciencesImmunologyMedical specialtyMedicine

Identifiers

PMID41142112
PMCPMC12552917

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.