ArticleThe journal of allergy and clinical immunology. Global2025
Effectiveness and safety of algorithm for treating pregnant women with syphilis and history of immediate allergy to penicillin.
Article in The journal of allergy and clinical immunology. Global, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Rapid food desensitization supported by omalizumab, with adjunctive dupilumab for type 2 comorbidities: A pediatric case series.The World Allergy Organization journal · 2026Article
- Treatment of Syphilis in Pregnancy and Congenital Syphilis: Current Evidence, Challenges, and Future Directions.Antibiotics (Basel, Switzerland) · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Penicillin is the only proven effective treatment for pregnant women with syphilis. Objective: We evaluated the efficacy and safety of an algorithm to guide reexposure to penicillin in pregnant women with syphilis and a history of allergy to the drug; and identified predictive biomarkers for successful desensitization. Methods: By using risk stratification, pregnant women with syphilis and a history of immediate hypersensitivity reaction to penicillin were reexposed to the drug through rapid desensitization or drug provocation test. Patients with a high-risk clinical history for anaphylaxis or positive skin test result underwent desensitization. Results: The study included 127 patients. Forty-nine (38.6%) had high-risk clinical history for anaphylaxis and were desensitized, while 78 (61.4%) were at low risk and with negative skin test results underwent challenge. Skin test results were positive in 7.9% of all patients. These patients underwent desensitization, and 40% experienced a reaction. There was an association between positive skin test results and reaction during desensitization ( Conclusion: Our algorithm for managing immediate reactions to penicillin is effective and safe. Skin testing identifies patients at higher risk for reactions. This study enables the identification of pregnant women with a history of high risk for immediate hypersensitivity to penicillin, allowing for safe desensitization treatment, or can offer low-risk pregnant women the option to delabel the allergy through a provocation test.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.