Wellbeing for staff in UKCRC-registered Clinical Trials Units: Development of the Flourishing As Clinical Trial Staff (FACTS) guidance: a mixed-methods study.

Sophie S Hall, Evgenia Riga, Eleanor J Mitchell, Louise Thomson, Jodi Taylor, Lucy Carr, Pamela Hagan, Kirsty Sprange

Abstract read

In one paragraph

Article in Contemporary clinical trials communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Walking the tightrope of justifiable decision‑making: An exploratory qualitative study identifying barriers and solutions to efficient safety reporting.PloS one · 2026
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sophie S HallNottingham Clinical Trials Unit, School of Medicine, University of Nottingham, Nottingham, UK.

Evgenia RigaNottingham Clinical Trials Unit, School of Medicine, University of Nottingham, Nottingham, UK.

Eleanor J MitchellNottingham Clinical Trials Unit, School of Medicine, University of Nottingham, Nottingham, UK.

Louise ThomsonFaculty of Medicine and Health Sciences, University of Nottingham, Nottingham, UK.

Jodi TaylorBristol Trials Centre, University of Bristol, Bristol, UK.

Lucy CarrSheffield Clinical Trials Research Unit, University of Sheffield, Sheffield, UK.

Pamela HaganFaculty of Medicine and Health Sciences, University of Nottingham, Nottingham, UK.

Kirsty SprangeNottingham Clinical Trials Unit, School of Medicine, University of Nottingham, Nottingham, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Evaluating healthcare interventions in clinical trials requires a skilled workforce. However, the demands of developing and running clinical trials make recruiting and retaining staff challenging. Flourishing, which focuses on positive aspects of well-being, may help staff manage these demands. This study introduces the Flourishing As Clinical Trial Staff (FACTS) guidance, offering practical strategies to support staff working in UK Clinical Research Collaboration (UKCRC) Clinical Trials Units (CTUs), to thrive at work. Methods: Building upon findings from a national survey of staff working in UKCRC CTUs, a three-phase consensus-based approach was used to develop recommendations to support flourishing in clinical trial staff; (1) focus groups with staff (n = 24), (2) a consensus survey (n = 21) and (3) a consensus workshop (n = 15). Results: The focus groups identified strategies for supporting CTU staff to flourish, including factors relating to the Conclusions: The FACTS guidance includes recommendations to support UKCRC CTU staff to flourish in their work and are likely to apply more broadly to research institutions conducting clinical trials. The recommendations provide a foundation for CTUs to review and adapt to their local needs over time. Implementing these recommendations may prove beneficial for increasing job satisfaction and commitment, which is likely to facilitate efficient trial delivery.

Indexed as

Clinical trialsClinical trial staffEmployee wellbeingEudaimonic wellbeingFlourishingJob satisfactionWorkplace wellbeing

Identifiers

PMID41142040

DOI10.1016/j.conctc.2025.101556

PMCPMC12549786

What OpenQuestion holds

Textmetadata

LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.