Evidence map›Paper›PMID 41142010›Full record

ArticleOncology reviews2025

Global trends of esophageal cancer among individuals over 60 years: an epidemiological analysis from 1990 to 2050 based on the global burden of disease study 1990-2021.

Simiao Lu, Kexun Li, Kangning Wang, Guangyuan Liu, Yongtao Han, Lin Peng, Lei Chen, Xuefeng Leng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncology reviews, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Simiao Lu *Department of Thoracic Surgery, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, University of Electronic Science and Technology of China (UESTC), Chengdu, China.
Kexun Li *Department of Thoracic Surgery, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, University of Electronic Science and Technology of China (UESTC), Chengdu, China.
Kangning WangDepartment of Thoracic Surgery, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, University of Electronic Science and Technology of China (UESTC), Chengdu, China.
Guangyuan LiuDepartment of Thoracic Surgery, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, University of Electronic Science and Technology of China (UESTC), Chengdu, China.
Yongtao HanDepartment of Thoracic Surgery, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, University of Electronic Science and Technology of China (UESTC), Chengdu, China.
Lin PengDepartment of Thoracic Surgery, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, University of Electronic Science and Technology of China (UESTC), Chengdu, China.
Lei ChenDepartment of Oncology and Cancer Institute, Sichuan Academy of Medical Sciences, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China.
Xuefeng LengDepartment of Thoracic Surgery, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, University of Electronic Science and Technology of China (UESTC), Chengdu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Esophageal cancer (EC) ranks as the sixth leading cause of cancer-related deaths globally, with over 500,000 new cases annually. Understanding trends in individuals over 60 is critical for enhancing treatment and the success of early diagnosis and screening. Materials and methods: This study analyzed global, regional, and national trends in EC management among individuals aged 60 years and older, spanning from 1990 to 2021, utilizing data from the Global Burden of Disease Study 2021. We employed the integrating differential equations to enhance the accuracy of incidence, prevalence, mortality, and Disability-Adjusted Life Years (DALYs). The Bayesian Age-Period-Cohort (BAPC) model was also used to forecast future trends up to 2050. Results: Our findings indicate significant shifts in the EC burden among those over 60, with a notable increase in absolute numbers from 1990 to 2021, despite a decline in age-standardized rates. The incidence rose by 185%, while the age-standardized prevalence rate decreased by 17.02%. Socioeconomic factors, indicated by the Social Demographic Index, revealed varying trends across different regions and income levels, highlighting the influence of economic status on EC outcomes. Conclusion: Analysis indicates varying trends across different regions. Behavioral risk factors, particularly smoking and alcohol use, significantly contribute to the burden of EC, especially among males. Projections suggest that despite declining age-standardized rates, the absolute number of cases, deaths, and DALYs will continue to rise due to population growth and aging, highlighting the ongoing global challenge of EC.

Indexed as

esophageal cancerglobal burden of diseaseincidencemanagementmortality

Identifiers

PMID41142010
PMCPMC12547927

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.