SynthesisFrontiers in pediatrics2025
The effects of alfentanil on emergence agitation in children under general anesthesia: a meta-analysis of randomized controlled trials.
Synthesis in Frontiers in pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Emergence agitation (EA) is characterized by excessive reactivity and sensory impairment that occurs in children after general anesthesia. Alfentanil is a µ-opioid receptor with rapid onset and short duration, widely used in minor surgery. The aim of this meta-analysis is to assess the effect of alfentanil on the incidence of EA in children undergoing general anesthesia. Methods: PubMed, Cochrane Library, Embase, and Web of Science databases were reviewed to search for related trials published before April 30, 2025. The primary outcome was the incidence of EA. Secondary outcomes included rescue analgesia, postoperative nausea and vomiting (PONV), emergence time, extubation time, and time to discharge from post-anesthesia care unit (PACU). Results: The study extracted from 5 studies including 532 patients. Compared to saline, alfentanil reduced the incidence of EA in children (RR = 0.54; 95% CI: 0.42-0.70; Conclusions: Limited available evidence suggests that alfentanil is associated with a lower incidence of EA in children. However, further high-quality studies are needed to verify the effect of alfentanil in preventing the occurrence of EA in children undergoing general anesthesia. Systematic Review Registration: https://www.crd.york.ac.uk/PROSPERO/view/CRD42023448260, PROSPERO CRD42023448260.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.