ArticleFrontiers in pediatrics2025
Evaluation of gestational age, serum amyloid A, and hemoglobin decline (ΔHb) as diagnostic markers for NEC secondary to late-onset sepsis in preterm infants.
Article in Frontiers in pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Risk factors of necrotizing enterocolitis in very low birth weight infants: a meta-analysis.Frontiers in pediatrics · 2026Review
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5 authors.
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Abstract
Objective: To evaluate gestational age, serum amyloid A (SAA), and hemoglobin decline (ΔHb) as diagnostic markers for necrotizing enterocolitis (NEC) secondary to late-onset sepsis (LOS) in preterm infants. Methods: A retrospective study was conducted on 77 preterm infants with LOS admitted to Anhui Provincial Children's Hospital from January 1, 2019, to October 31, 2024. The infants were divided into an NEC group (24 cases) and a non-NEC group (53 cases). Perinatal factors, initial blood counts, C-reactive protein, and SAA levels during early LOS were recorded. ΔHb was calculated as the difference between pre-LOS Hb concentration and initial Hb concentration at LOS onset. Differences were analyzed using the Mann-Whitney Results: The NEC group had significantly lower birth weight, gestational age, white blood cell count, neutrophil count, and lymphocyte count compared to the non-NEC group. In contrast, SAA, ΔHb, asphyxia incidence, and ventilator use rate were significantly higher in the NEC group ( Conclusion: Gestational age, SAA, and ΔHb appear to be useful indicators for predicting NEC secondary to LOS in preterm infants. The ease of obtaining these indicators and their low cost make them suitable for clinical application. However, this study was retrospective with certain uncontrollable factors and a relatively small sample size. Larger prospective studies are recommended for further validation.
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