ArticleNew microbes and new infections2025
Prevalence and characterization of third-generation cephalosporin, carbapenem and colistin-resistant Enterobacterales isolated from clinical samples in Cambodia.
Article in New microbes and new infections, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objectives: Despite the threat of antimicrobial resistance (AMR) worldwide, limited studies describe the situation in human infections in Cambodia. Our study aims to evaluate the current state of AMR and describe the resistance mechanisms of the main Enterobacterales responsible for various infections in Cambodia. Methods: Between January and April 2020, 222 clinical Enterobacterales isolates were collected from routine diagnostics at the Medical Biology Laboratory of the Institut Pasteur du Cambodge, Phnom Penh. Antimicrobial susceptibility testing and resistance phenotype analysis were performed. Beta-lactamase genes Results: Overall, 39.2 % of isolates were resistant to at least one 3 GC, with 30.2 % confirmed as extended-spectrum beta-lactamase (ESBL) producers. The corresponding ESBL genes pertain to the KLUB/CTX-M-1 and KLUY/CTX-M-9 classes. Carbapenemase genes Conclusion: The prevalence and molecular characterization of 3 GC-resistant and ESBL-producing Enterobacterales in our study is consistent with recent reports. Our findings further confirm the high rate of carbapenemase producing Enterobacterales (NDM and OXA-48), including in community-acquired infections. Additionally, we report notable colistin resistance among ESBL producing
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