Evaluation of Various Magnetic Ferrite Nanoparticles for Methionine γ‑Lyase (MGL) Immobilization: Enhanced Stability and Catalytic Performance of Nanoenzyme Carriers.

Rahmaga Febriansyah, Montisa Mangkalee, Kittisak Thotsaporn, Chompoonut Rungnim, Panyakorn Taweechat, Pornthep Sompornpisut, Khemika Wannakan, Watcharaphol Paritmongkol, Numpon Insin

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Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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5 · Who and what money

Authors and funding

9 authors.

Rahmaga FebriansyahDepartment of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand.

Montisa MangkaleeDepartment of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand.

Kittisak ThotsapornResearch Unit in Integrative Immuno-Microbial Biochemistry and Bioresponsive Nanomaterials, Faculty of Dentistry, Chulalongkorn University, Pathumwan, Bangkok 10330, Thailand.

Chompoonut RungnimMetallurgy and Materials Science, Research Institute, Chulalongkorn University, Soi Chula 12, Phayathai Road, Pathumwan, Bangkok 10330, Thailand.ORCID https://orcid.org/0000-0002-2794-5253

Panyakorn TaweechatCenter of Excellence in Computational Chemistry, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand.

Pornthep SompornpisutCenter of Excellence in Computational Chemistry, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand.ORCID https://orcid.org/0000-0002-8029-332X

Khemika WannakanDepartment of Materials Science and Engineering, School of Molecular Science and Engineering, Vidyasirimedhi Institute of Science and Technology (VISTEC), Rayong 21210, Thailand.

Watcharaphol ParitmongkolDepartment of Materials Science and Engineering, School of Molecular Science and Engineering, Vidyasirimedhi Institute of Science and Technology (VISTEC), Rayong 21210, Thailand.ORCID https://orcid.org/0000-0003-1638-6828

Numpon InsinDepartment of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand.ORCID https://orcid.org/0000-0002-7307-5439

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Methionine γ-lyase (MGL), a methionine-starvation enzyme, has garnered significant attention for its potential applications in targeting methionine-dependent cancer cells. Here, we report the successful immobilization of His-tagged MGL onto magnetic ferrite nanoparticles (MF MNPs) supports functionalized with modified Nα, Nα-bis-(carboxymethyl)-l-lysine (Ni-mANTA), exploiting both the magnetic core and surface complexation to enhance MGL's stability and catalytic performance. Ferrite support cores containing Ni

Identifiers

PMID41141795

DOI10.1021/acsomega.5c04461

PMCPMC12547537

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LicenceCC BY-NC-ND

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.