Evidence map›Paper›PMID 41141754›Full record

ArticleACS omega2025

Evaluating the Enantioselective Neurotoxicity of Organophosphorus Pollutant Dioxabenzofos: Mechanistic Studies Employing Cellular, Molecular, and Computational Toxicology Assays.

Zhi-Cong He, Tao Zhang, Xin-Fang Lu, Rui Li, Qiong Mei, Qi-Zhao Wang, Fei Ding, Wei Peng

Abstract read
In one paragraph

Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zhi-Cong HeState Key Laboratory of Microbial Technology, Shandong University, Qingdao 266237, China.
Tao ZhangSchool of Water and Environment, Key Laboratory of Subsurface Hydrology and Ecological Effect in Arid Region of Ministry of Education, Key Laboratory of Ecohydrology and Water Security in Arid and Semi-Arid Regions of Ministry of Water Resources, Chang'an University, Xi'an 710064, China.
Xin-Fang LuSchool of Water and Environment, Key Laboratory of Subsurface Hydrology and Ecological Effect in Arid Region of Ministry of Education, Key Laboratory of Ecohydrology and Water Security in Arid and Semi-Arid Regions of Ministry of Water Resources, Chang'an University, Xi'an 710064, China.
Rui LiSchool of Water and Environment, Key Laboratory of Subsurface Hydrology and Ecological Effect in Arid Region of Ministry of Education, Key Laboratory of Ecohydrology and Water Security in Arid and Semi-Arid Regions of Ministry of Water Resources, Chang'an University, Xi'an 710064, China.
Qiong MeiSchool of Water and Environment, Key Laboratory of Subsurface Hydrology and Ecological Effect in Arid Region of Ministry of Education, Key Laboratory of Ecohydrology and Water Security in Arid and Semi-Arid Regions of Ministry of Water Resources, Chang'an University, Xi'an 710064, China.
Qi-Zhao WangSchool of Water and Environment, Key Laboratory of Subsurface Hydrology and Ecological Effect in Arid Region of Ministry of Education, Key Laboratory of Ecohydrology and Water Security in Arid and Semi-Arid Regions of Ministry of Water Resources, Chang'an University, Xi'an 710064, China.
Fei DingSchool of Water and Environment, Key Laboratory of Subsurface Hydrology and Ecological Effect in Arid Region of Ministry of Education, Key Laboratory of Ecohydrology and Water Security in Arid and Semi-Arid Regions of Ministry of Water Resources, Chang'an University, Xi'an 710064, China.ORCID https://orcid.org/0000-0003-3241-4630
Wei PengState Key Laboratory of Microbial Technology, Shandong University, Qingdao 266237, China.ORCID https://orcid.org/0000-0002-4085-5842

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chiral organophosphorus pollutants are widely distributed in different environmental matrices, but their health risks to humans remain insufficiently explored. This study explored the acetylcholinesterase (AChE)-mediated enantioselective neurotoxicity of dioxabenzofos on SH-SY5Y cells and elucidated the microscopic mechanisms underlying neurotoxicity at the enantiomeric level. Cellular assays exhibited that dioxabenzofos displayed significant enantioselectivity in inhibiting the intracellular AChE activity, with IC

Identifiers

PMID41141754
PMCPMC12547560

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.