Evidence map›Paper›PMID 41141741›Full record

ArticleACS omega2025

Application Study on the Preparation of Curcumin/PVP Coprecipitated Particles Using Coaxial Nozzle in Supercritical Antisolvent.

Yechen Wang, Zirui Li, Fei Li, Wang Weiqiang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yechen WangKey Laboratory of High-efficiency and Clean Mechanical Manufacture(Ministry of Education), National Demonstration Center for Experimental Mechanical Engineering Education(Shandong University), School of Mechanical Engineering, Shandong University, Jinan 250061, PR China.ORCID https://orcid.org/0009-0006-9419-4206
Zirui LiKey Laboratory of High-efficiency and Clean Mechanical Manufacture(Ministry of Education), National Demonstration Center for Experimental Mechanical Engineering Education(Shandong University), School of Mechanical Engineering, Shandong University, Jinan 250061, PR China.
Fei LiKey Laboratory of High-efficiency and Clean Mechanical Manufacture(Ministry of Education), National Demonstration Center for Experimental Mechanical Engineering Education(Shandong University), School of Mechanical Engineering, Shandong University, Jinan 250061, PR China.
Wang WeiqiangKey Laboratory of High-efficiency and Clean Mechanical Manufacture(Ministry of Education), National Demonstration Center for Experimental Mechanical Engineering Education(Shandong University), School of Mechanical Engineering, Shandong University, Jinan 250061, PR China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The supercritical antisolvent-(SAS) technique serves as an environmentally benign processing method that effectively enhances the pharmacokinetic properties of poorly water-soluble drugs. Nevertheless, the existing supercritical fluid technology and processing methodologies remain underdeveloped, presenting significant barriers to large-scale industrial implementation. To overcome these limitations, a coaxial nozzle and its associated auxiliary apparatus were engineered. Taking curcumin as the research object, using polyvinylpyrrolidone-(PVP) as the polymer carrier, and ethanol and acetone as the organic solvents, curcumin/PVP coprecipitated particles were synthesized via the SAS process. A detailed examination was conducted to evaluate the influence of key processing parametersincluding acetone/ethanol-(Ac/EtOH) volume ratio, curcumin/PVP mass ratio, temperature, pressure, and solution concentrationon the particle size and distribution of the resulting coprecipitates. The coprecipitate was characterized by various characterization methods. The findings reveal that the SAS process effectively generated amorphous curcumin/PVP coprecipitates with a submicron-scale particle diameter of 337 ± 47 nm. These findings confirm the great potential of the SAS method in the production of polymer-drug composite systems.

Identifiers

PMID41141741
PMCPMC12547586

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.