SynthesisFrontiers in surgery2025
Adipose tissue and fat-derived products in wound, ulcer, and scar management: a systematic review.
Synthesis in Frontiers in surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Adipose-derived therapies hold promise in addressing the increasing prevalence of skin wounds, scars, and ulcers. This systematic review, conducted following the PRISMA guidelines, evaluates the therapeutic potential of adipose derived stem cells for improving wound healing, scar development and ulcer management. Methods: An extensive search was conducted across PubMed, EMBASE, Scopus, Web of Science, Cochrane Central, and LILACS. The search strategy employed a combination of keywords and Medical Subject Headings (MeSH) terms related to "adipose tissue", "fat derivatives", "ulcers", "wound healing", and their synonyms, covering articles published from inception to October 2024. Our search yielded 589 records, with 16 randomized clinical trials and two ongoing studies meeting inclusion criteria after screening and full-text assessment. Results: Findings indicate that adipose-derived therapies significantly enhance wound healing, reduce pain, and improve cosmetic appearance, patient satisfaction, and health-related quality of life compared to conventional treatments. Discussion: These therapies demonstrate efficacy across various wound types and scars, with a favorable safety profile. However, further standardized protocols and large-scale randomized trials are essential to validate these outcomes and assess longterm safety. While adipose-derived therapies show promise in enhancing wound healing and managing scars, ongoing research is essential to facilitate their integration into routine clinical practice. Systematic Review Registration: https://www.crd.york.ac.uk/PROSPERO/view/CRD42024503209, PROSPERO CRD42024503209.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.