SynthesisFrontiers in surgery2025
The role of nutritional and inflammatory markers in predicting postoperative complications after esophagectomy for esophageal squamous cell carcinoma: mechanisms, clinical applications, and future perspectives.
Synthesis in Frontiers in surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association between the prognostic nutritional index and prognosis in patients with non-small cell lung cancer undergoing curative lung resection: a systematic review and meta-analysis.Frontiers in oncology · 2026Pooled it
- An inflammation-nutrition composite index and its dynamic change for predicting postoperative wound complications.Langenbeck's archives of surgery · 2026Observational
- Preoperative prediction of lymph node metastasis in lung adenocarcinoma based on tumor size and carcinoembryonic antigen.Journal of thoracic disease · 2026Article
- Preoperative Aggregate Index of Systemic Inflammation is Associated with 30-Day Postoperative Pneumonia After Minimally Invasive Esophagectomy for Esophageal Squamous Cell Carcinoma: A Retrospective Cohort Study.Infection and drug resistance · 2026Article
- Comparative analysis on the effect of vagus nerve stimulation in reducing post-operative inflammation and enhancing recovery outcomes after surgery.Bioinformation · 2026Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Esophageal squamous cell carcinoma (ESCC) is a prevalent malignancy with a high mortality rate, for which esophagectomy remains the cornerstone of curative treatment. However, this complex surgical procedure is associated with significant postoperative morbidity and mortality. Nutritional status and systemic inflammatory response are critically intertwined and play a pivotal role in the host's ability to withstand surgical stress and mount an effective recovery. This review aims to provide a comprehensive overview of the role of nutritional and inflammatory markers in predicting postoperative complications following esophagectomy for ESCC. We first elucidate the intricate biological mechanisms through which malnutrition and systemic inflammation compromise tissue repair, immune function, and overall surgical outcomes. We then systematically evaluate the predictive value of various individual markers, such as albumin, C-reactive protein (CRP), and neutrophil-to-lymphocyte ratio (NLR), as well as combined scoring systems like the Prognostic Nutritional Index (PNI) and the Glasgow Prognostic Score (GPS). The clinical application of these markers in preoperative risk stratification, guiding perioperative immunonutrition, and dynamic monitoring for early complication detection is thoroughly discussed. Finally, we highlight future perspectives, including the integration of novel biomarkers from metabolomics and proteomics, the application of artificial intelligence in building sophisticated prediction models, and the design of marker-guided precision intervention trials. A deeper understanding and smarter utilization of these readily available and cost-effective markers will pave the way for personalized perioperative management, ultimately improving the prognosis for patients with ESCC undergoing esophagectomy.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.