ArticleTranslational pediatrics2025
Predictive significance of peripheral blood IL-6 and FeNO in pediatric
Article in Translational pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Methods: A total of 120 pediatric patients with MP infection admitted to our hospital from June 2021 to May 2023 were stratified into an AHR cohort (n=45) and a non-AHR cohort (n=75) based on the presence or absence of AHR. General patient information, IL-6 and FeNO levels, lung function indices [forced vital capacity (FVC), forced expiratory volume in one second (FEV Results: Proportions of the AHR cohort with fever duration ≥7 days (P=0.02) and antibiotic initiation ≥7 days (P=0.02) were significantly higher than those in the non-AHR cohort. The AHR cohort exhibited significantly higher levels of peripheral blood IL-6 (P<0.001), HMGB1 (P<0.001), TLR4 (P=0.01), NF-κB (P=0.01), and FeNO (P<0.001) and lower values of FEV1 (P=0.04), FVC (P<0.001), and PEF (P<0.001). Pearson correlation demonstrated that IL-6 and FeNO were positively correlated with HMGB1, TLR4, and NF-κB (r>0, P<0.001), and inversely correlated with FEV Conclusions: Peripheral blood levels of IL-6 and FeNO were significantly elevated in children with MP infection and AHR. These markers were associated with lung function and the HMGB1/TLR4/NF-κB signaling pathway. Their combined assessment could effectively predict the co-incurrence of AHR in patients with MP infection.
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