ArticleOsteoarthritis and cartilage open2025
Exploring the relationship between allostatic load and osteoarthritis: A cross-sectional analysis from the North West Adelaide Health Study.
Article in Osteoarthritis and cartilage open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 authors.
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Abstract
Objective: Cumulative stress-response system dysregulation, known as allostatic load (AL), is suggested as a possible mechanism that may connect upstream health determinants with OA. Our objective was to evaluate the cross-sectional association between AL and the presence of OA. Design: This cross-sectional study used Stage Two (2004-2006) data from the North West Adelaide Health Study (NWAHS), a population-based cohort study. Osteoarthritis and joint pain were defined using self-report and medication data. Allostatic load was a composite index of nine equally-weighted biomarkers; systolic and diastolic blood pressures, waist-hip ratio, body mass index, total cholesterol, high-density lipoprotein, glycated haemoglobin, interleukin 6 and tumour necrosis factor alpha. Binary logistic regression models estimated the association between AL and OA, with adjustment for demographic, health behaviour and comorbidity covariates. Results: Overall, 1600 participants were eligible for inclusion in the analysis. The OA group ( Conclusions: There is a cross-sectional association between AL and the presence of OA and self-reported joint pain. Further investigations are warranted using longitudinal data.
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